Role of ASXL1 in Hematopoiesis and Myeloid Diseases

Mammalian ASXL family genes (ASXL1, ASXL2 and ASXL3) are the mammalian homologs of Drosophila Additional sex combs Asx (1). Asx deletion leads to a homeotic phenotype characteristic of both Polycomb group (PcG, repressive complex associated with H3K27me3) and Trithorax group (TrxG, activating function associated with H3K4me3) gene deletions (1-3). Both Asxl1 and Asxl2 expression is virtually ubiquitous throughout embryogenesis and in adult tissues, whereas Asxl3 expression is more restricted and only detectable in lymph node, eye, lung, skin, brain, and pituitary gland (4).

Source: Experimental Hematology - September 29, 2022 Category: Hematology Authors: Xin Gao, Xiaona You, Nathalie Droin, Lauren G Banaszak, Jane Churpek, Eric Padron, Klaus Geissler, Eric Solary, Mrinal M. Patnaik, Jing Zhang Tags: Review Source Type: research