Ischemic Preconditioning Alleviates Cerebral Ischemia –Reperfusion Injury by Interfering With Glycocalyx

This study found that (1) IPC improved brain infarction and edema, neurological impai rment, and BBB disruption in IRI rats; (2) IPC significantly up-regulated HA ratio and down-regulated HS ratio, but did not affect SYND1 ratio compared with the IRI group. Moreover, the increased HA ratio was negatively related to brain edema and neurological deficit score. (3) IPC affected HA metab olism by up-regulating hyaluronate synthase-1 and matrix metalloproteinase-2, and down-regulating hyaluronidase-1 in brain tissue. Together, this is the first report that the neuroprotective effect of IPC on IRI may be mediated through interfering with glycocalyx in the MCAO/R model.
Source: Translational Stroke Research - Category: Neurology Source Type: research