Crosstalk between TBK1/IKK ε and the type 1 interferon pathway contributes to tubulointerstitial inflammation and kidney tubular injury

In conclusion, T1-IFNs, TWEAK, and LPS engage interrelated proinflammatory and antiviral responses in tubular cells. Moreover, inhibition of TBK1/IKKε with amlexanox, and IFNAR targeting, may protect from tubulointerstitial kidney injury.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research