New possibilities for chromoblastomycosis and phaeohyphomycosis treatment: identification of two compounds from the MMV Pathogen Box ® that present synergism with itraconazole

CONCLUSIONS: These compounds in combination, particularly SQ109, are promising candidates to treat Fonsecaea spp. and E. dermatitidis infections, which account for most cases of chromoblastomycosis and phaeohyphomycosis.PMID:36102413 | PMC:PMC9467274 | DOI:10.1590/0074-02760220089

Source: Memorias do Instituto Oswaldo Cruz - September 14, 2022 Category: Infectious Diseases Authors: Rowena Alves Coelho Gabriela Machado Alves Maria Helena Galdino Figueiredo-Carvalho Fernando Almeida-Silva Gabriela Rodrigues de Souza Maria Cristina da Silva Louren ço F ábio Brito-Santos Ana Claudia Fernandes Amaral Rodrigo Almeida-Paes Source Type: research