Drug Exposure and Risk of Microscopic Colitis: A Systematic Review and Meta-analysis

Background and objectives: Microscopic Colitis (MC) is a chronic inflammatory bowel disease, characterized by watery diarrhoea, normal radiological and endoscopic appearance. Concern regarding a potential association between drug exposure and MC has recently emerged. We sought to systematically review and summarize the evidence for the potential association. Methods: A systematic review and meta-analysis were performed to evaluate the incidence of MC associated with exposure to drug. The PubMed and Embase databases were searched to identify potential studies for inclusion. Results: Twelve case-control studies were included in the meta-analysis. The results showed exposure to NSAID (OR, 1.64; 95% CI 1.14-2.37; P
Source: Digestive Diseases - Category: Gastroenterology Source Type: research