Membrane transporters control cerebrospinal fluid formation independently of conventional osmosis to modulate intracranial pressure

ConclusionsCSF secretion appears to not rely on conventional osmosis, but rather occur by a concerted effort of different choroidal transporters, possibly via a molecular mode of water transport inherent in the proteins themselves. Therapeutic modulation of the rate of CSF secretion may be employed as a strategy to modulate ICP. These insights identify new promising therapeutic targets against brain pathologies associated with elevated ICP.
Source: Fluids and Barriers of the CNS - Category: Neuroscience Source Type: research