Imiquimod-induced ROS production causes lysosomal membrane permeabilization and activates caspase-8-mediated apoptosis in skin cancer cells

Lysosomal cell death is induced by lysosomal membrane permeabilization (LMP) and the subsequent release of lysosomal proteolytic enzymes, including cathepsins (CTSs), which results in mitochondrial dysfunction and apoptosis. Imiquimod (IMQ), a synthetic TLR7 ligand, has both antiviral and antitumor activity against various skin malignancies in clinical treatment. Previously, we demonstrated IMQ not only caused lysosomal dysfunction but also triggered lysosome biogenesis to achieve lysosomal adaptation in cancer cells.

Source: Journal of Dermatological Science - August 25, 2022 Category: Dermatology Authors: Shu-Hao Chang, Pei-Ying Lin, Tsai-Kun Wu, Chien-Sheng Hsu, Shi-Wei Huang, Zheng-Yi Li, Kuang-Ting Liu, Jun-Kai Kao, Yi-Ju Chen, Tak-Wah Wong, Chun-Ying Wu, Jeng-Jer Shieh Source Type: research