Molecules, Vol. 27, Pages 5468: Design, Synthesis and Structure-Activity Relationship of Novel Pinacolone Sulfonamide Derivatives against Botrytis cinerea as Potent Antifungal Agents
Molecules, Vol. 27, Pages 5468: Design, Synthesis and Structure-Activity Relationship of Novel Pinacolone Sulfonamide Derivatives against Botrytis cinerea as Potent Antifungal Agents
Molecules doi: 10.3390/molecules27175468
Authors:
Chaojie Liu
Xiaofang Xiang
Ying Wan
Jia Yang
Yufei Li
Xinchen Zhang
Zhiqiu Qi
Lu He
Wei Liu
Xinghai Li
To develop new fungicides with high efficiency, 46 novel sulfonamide derivatives were designed and synthesized by introducing pinacolone fragment into chesulfamide which was used as lead compound. All compounds were characterized by 1H NMR, 13C NMR, and MS spectra, and the structure of compound P-27 was also confirmed by X-ray single crystal diffraction. It was found that a variety of compounds present excellent inhibitory effect against Botrytis cinerea. The inhibition rates of P-29 on tomato and strawberry were 90.24% (200 mg/L) and 100% (400 mg/L) in vivo respectively, which were better than the lead compound chesulfamide (59.23% on tomato seedlings and 29.63% on strawberries).
Source: Molecules - Category: Chemistry Authors: Chaojie Liu Xiaofang Xiang Ying Wan Jia Yang Yufei Li Xinchen Zhang Zhiqiu Qi Lu He Wei Liu Xinghai Li Tags: Article Source Type: research