Commentary: Bigger is Not Always Better

In Decellularized vs Non-decellularized Allogeneic Pulmonary Artery Patches for Pulmonary Arterioplasty Bonilla-Ramirez et al. investigate the differential effect of decellularized (DAPAP) and cryopreserved pulmonary allograft (non-DAPAP) on pulmonary artery remodeling following Glenn.1 The authors show that DAPAP is associated with higher pulmonary artery z-score and lower need for reintervention. Their results suggest improved short and long-term outcomes, which they attribute to the theoretical reconstitution of the DAPAP patch, more physiological growth, and lower immunogenicity in a patient population who uniformly face transplantation.
Source: Seminars in Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: CONGENITAL – Commentary Source Type: research