Dentinogenic ghost cell tumor with focal features suggesting ghost cell odontogenic carcinoma: a challenging diagnosis

Dentinogenic ghost cell tumor and ghost cell odontogenic carcinoma form a spectrum of rare benign and malignant odontogenic neoplasms, respectively. A 24-year-old White woman complained of a painful enlargement and dental mobility in the maxilla for approximately 1 year. An intraoral examination showed a 3  × 3 cm firm exophytic mass in the left molar region. Tomographic sections showed a well-defined hypodense expansion with hyperdense foci inside invading the maxillary sinus. Microscopically, incisional sections showed a predominantly solid basaloid epithelium presenting atypical features, mito tic activity, ghost cells, positivity for p53, and high Ki-67 labeling, suggesting malignancy.

Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - August 17, 2022 Category: ENT & OMF Authors: Gustavo De Souza Vieira, P âmella De Pinho Montovani, João Pedro Roque Beserra, Mauro César Gaspar Ribeiro, Rafaela Elvira Rozza-De-Menezes, Karin Soares Gonçalves Cunha, Danielle Castex Conde Source Type: research