Nm23-H1 induces apoptosis in primary effusion lymphoma cells via inhibition of NF- κB signaling through interaction with oncogenic latent protein vFLIP K13 of Kaposi’s sarcoma-associated herpes virus

ConclusionDownregulation of Nm23-H1 expression in KSHV-infected PEL cells and its overexpression trigger apoptosis by impairing vFLIP K13-driven NF- κB signaling, suggesting therapeutic implications of Nm23-H1 for primary effusion lymphomas.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research