IgG4 Valency Modulates the Pathogenicity of Anti-Neurofascin-155 IgG4 in Autoimmune Nodopathy

Discussion
Our findings demonstrate that monospecific and bivalent anti-Nfasc155 IgG4 are detected in patients and that those autoantibodies are the pathogenic ones. The transformation of anti-Nfasc155 IgG4 into monovalent Fab or functionally monovalent IgG4 through FAE strongly decreases paranodal alterations. Bivalency thus appears crucial for Nfasc155 clustering and paranode destruction.

Source: Neurology Neuroimmunology and Neuroinflammation - August 10, 2022 Category: Neurology Authors: Jentzer, A., Attal, A., Roue, C., Raymond, J., Lleixa, C., Illa, I., Querol, L., Taieb, G., Devaux, J., on behalf of the anti-neurofascin-155 study group Tags: Research Article Source Type: research