BMI1 promotes cholangiocarcinoma progression and correlates with antitumor immunity in an exosome-dependent manner

CONCLUSIONS: BMI1 is an unfavorable prognostic biomarker of CCA. Our data depict a novel function of BMI1 in CCA tumorigenesis and metastasis mediated by exosomes. Besides, BMI1 inhibition may augment immune checkpoint blockade to inhibit tumor progression by activating cell-intrinsic immunity of CCA.PMID:35932322 | DOI:10.1007/s00018-022-04500-1
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Source Type: research