Silk fibroin and Nettle extract promote wound healing in a rat model: A histological and morphometrical study

CONCLUSION: Nettle and SF maintain cell homeostasis and accelerate wound closure by reducing cell apoptosis and enhancing cell proliferation on the seventh day, but by increasing the apoptosis of fibroblast cells on the fourteenth day, they lead to remodeling and keratinocytes migration to epidermis formation. Increased apoptosis also seems to be one of the pathophysiological mechanisms to prevent the formation of keloid and hypertrophic scar tissue. SF and Nettle extract, by increasing cell proliferation and migration of different cell types to the site of injury, control the remodeling process by inducing and regulating apoptosis in the first two weeks of wound healing and accelerating the process of collagen deposition and epithelialization.PMID:35917633 | DOI:10.1016/j.acthis.2022.151930

Source: Acta Histochemica - August 2, 2022 Category: Biochemistry Authors: Hamid-Reza Alizadeh-Otaghvar Fatemeh Moradi Nader Sadigh Amir Raoofi Shahram Darabi Auob Rustamzadeh Tayyeb Ghadimi Mohammad Jafar Rezaie Elham Seidkhani Reza Ahadi Ronak Shabani Amin Mousavi-Khaneghah Sona Zare Source Type: research