Comparison of 11C-Pittsburgh Compound B and 18F-Flutemetamol White Matter Binding in PET

Conclusion: 11C-PiB and 18F-flutemetamol show a similar topographic pattern of uptake in white matter with a similar association with age in WMH and NAWM. 11C-PiB and 18F-flutemetamol can also effectively distinguish between WMH and NAWM. However, given its longer half-life, commercial availability, and higher binding potential, 18F-flutemetamol can be an alternative to 11C-PiB in molecular imaging studies specifically targeting multiple sclerosis to evaluate white matter integrity.

Source: Journal of Nuclear Medicine - August 1, 2022 Category: Nuclear Medicine Authors: Zeydan, B., Schwarz, C. G., Przybelski, S. A., Lesnick, T. G., Kremers, W. K., Senjem, M. L., Kantarci, O. H., Min, P. H., Kemp, B. J., Jack, C. R., Kantarci, K., Lowe, V. J. Tags: Clinical Investigations Source Type: research