Mutagenic effect of chemotherapy on sperm DNA and implications for family planning

Nature Reviews Urology, Published online: 29 July 2022; doi:10.1038/s41585-022-00625-xSome chemotherapeutic agents can induce distinct mutational signatures in healthy cells in patients with cancer. The effect of such mutational signatures on spermatogenesis is not fully understood but is of great clinical importance for counselling patients diagnosed with cancer planning to start a family after treatment.

Source: Nature Reviews Urology - July 29, 2022 Category: Urology & Nephrology Authors: Ari P. Bernstein Justin Loloi Rohit Reddy Christian Ramsoomair Katherine Campbell Francesco Maura Ola Landgren Daniel Nassau Emad Ibrahim Ranjith Ramasamy Source Type: research