Olfactory swab sampling optimization for α-synuclein aggregate detection in patients with Parkinson’s disease

ConclusionIn PD patients, RT-QuIC sensitivity is significantly increased (from 45% to 84%) when NS is performed at AN, indicating that α-syn aggregates are preferentially detected in olfactory areas with higher concentration of olfactory neurons. Although RT-QuIC analysis of CSF showed a higher diagnostic accuracy compared to NS, due to the non-invasiveness, NS might be considered as an ancillary procedure for PD diagnosis.
Source: Translational Neurodegeneration - Category: Neurology Source Type: research