732 Treatment with cyclohexyl salicylate, an olfactory receptor 2A4/7 agonist, promotes human hair follicle growth and bulge stem cell progeny expansion

Topically applicable non-drugs that enhance the efficacy of available FDA-licensed drugs would be a welcome therapeutic addition in hair loss management. Since the olfactory receptor (OR) agonist, Sandalore, promotes human hair growth and reduces telogen effluvium, we have explored here whether other cosmetic OR ligands can unfold similar properties. We focused on OR2A4/7, since its stimulation promotes epidermal keratinocyte proliferation and differentiation. In situ hybridization showed that OR2A4/7 mRNA is widely expressed in the hair follicle (HF) epithelium, namely the outer root sheath (ORS) and hair matrix (HM).
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Source Type: research