Reduced Bone Mineral Density in Middle-Aged Male Patients with Adult Growth Hormone Deficiency
Horm Metab Res 2022; 54: 450-457 DOI: 10.1055/a-1850-7461The aim of the work was to investigate the bone mineral density (BMD) in
middle-aged male patients with both childhood-onset (CO) and adulthood-onset
(AO) adult growth hormone deficiency (AGHD). In this retrospective
cross-sectional study in a major medical center in China, dual X-ray
absorptiometry was performed in 50 male AGHD patients (average age was
35.2±9.8 years) and 50 age- and BMI-matched non-athletic healthy men.
BMD was compared between AGHD patients and controls. Compared with healthy
controls, AGHD group had significantly decreased IGF-1 (p1<0.001) and
IGF-1 SDS (p1<0.001). Serum testosterone levels were significantly lower
in AGHD patients (p1<0.001), mainly in AO AGHD patients
(p3<0.001). The BMD of the femoral neck, trochanter, femoral shaft,
total hip, and lumbar spine were significantly lower in all AGHD patients
compared with healthy controls (all p1<0.05), especially in CO AGHD
patients (all p2<0.05). Multiple stepwise linear regression indicated
AGHD was negatively correlated with BMD at each site (β<0,
p<0.05). Additionally, serum testosterone level was an independent
influencing factor of BMD of the femoral neck (β=0.256,
p=0.018) and lumbar spine (β=0.219, p=0.040).
BMD was significantly redu...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Liu, Shanshan Yang, Hongbo Xu, Hanyuan Zhou, Zhibo Bai, Xi Wang, Linjie Duan, Lian Gong, Fengying Zhu, Huijuan Pan, Hui Tags: Original Article: Endocrine Care Source Type: research