FGD5 marks a subpopulation of hematopoietic stem and progenitor cells that resist interferon- γ-mediated differentiation

The hematopoietic system is composed of dozens of cell types starting from the most primitive hematopoietic stem cells (HSCs) to terminally differentiated lineage cells [1]. Even within canonically defined populations, one can find heterogeneity in gene expression and function [2,3]. Although all hematopoietic trees are defined to start at a single population of HSCs, there is an accumulating compendium of evidence that supports how diverse HSCs can be, in terms of both function and gene expression [4 –9].
Source: Experimental Hematology - Category: Hematology Authors: Tags: Article Source Type: research