AEDG Peptide Prevents Oxidative Stress in the Model of Induced Aging of Skin Fibroblasts

AbstractUltraviolet (UV) radiation is one of the main environmental factors leading to oxidative stress and accelerated skin aging. AEDG peptide, a regulator of pineal gland functions, has demonstrated geroprotective and antioxidant effects in in vivo and in vitro studies. The aim of this research was to evaluate the effect of AEDG peptide on the expression of genes encoding enzymes of the antioxidant system (NQO1, SOD1, CATALASE, and TRXR) in human skin fibroblasts in a model of accelerated aging induced by UV radiation. The expression ofSOD1 andTXNRD1 genes during UV-induced aging of dermal fibroblasts increases by 2 and 1.7  times, respectively. This can be considered as a defense mechanism against oxidative stress caused by UV radiation. Photoaging does not influence the expression of theNQO1 andCATALASE genes in the culture of skin fibroblasts. AEDG peptide promotes the expression of theSOD-1,NQO1, andCATALASE genes in dermal fibroblasts exposed to UV radiation by 2.7, 2.6, and 3.2 times, respectively. AEDG peptide can stimulate the expression of these genes via the Keap1/Nrf2 signaling pathway. AEDG peptide might be potentially effective in preventing the accelerated aging of dermal fibroblasts.
Source: Advances in Gerontology - Category: Geriatrics Source Type: research