Frequency of extended spectrum β-lactamase producing urinary isolates of Gram-negative bacilli among patients seen in a multispecialty hospital in Vellore district, India

B Nandagopal, S Sankar, K Sagadevan, H Arumugam, MV Jesudason, K Aswathaman, A NairIndian Journal of Medical Microbiology 2015 33(2):282-285Extended-spectrum beta-lactamase (ESBL) producing strains of Coliform bacilli are on the rise and present a major threat especially in India. We assessed the frequency of ESBL producers among urinary isolates from patients presenting urinary tract infections. ESBL screening was done using Double Disk Synergy Test (DDST) and confirmed using E-test and Polymerase Chain Reaction (PCR). With E-test, 92.2% were positive for ESBL. In PCR, 100% strains were positive for any of the three gene targets tested. CTX-M was positive in majority of the strains followed by TEM and SHV. Two (3.22%) strains were positive for all the three genes; 21% strains were positive for both TEM and CTX-M genes. There was no statistically significant difference in the findings of E-test and PCR testing in the determination of ESBL producers (Fisher exact test P = 0.15). The strength of agreement between them was 'fair' (k = 0.252). Continuous monitoring of ESBL producers among Indian strains is important to rationalize the antibiotic policy to be followed.
Source: Indian Journal of Medical Microbiology - Category: Microbiology Authors: Source Type: research

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ConclusionGLASS is feasible to implement and more beneficial than laboratory-based surveillance. This study collects additional information beyond GLASS including causative bacteria and colonizing bacteria; types of UTI; and more specific criteria to distinguish HAI from CAI so that such data can be used for developing more valid local guidelines for selecting antibiotic therapy in UTI patients in addition to AMR surveillance in urine samples.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
No abstract available
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: ESPID Reports and Reviews Source Type: research
During my nine years in the NFL, I ruptured tendons in my fingers, suffered multiple concussions, and broke several bones. I tore my ACL, MCL, and PCL, and completely blew out my left knee. That last injury should have ended my career. But it didn’t. I put myself back together and played through the pain. What finally took me down? A tiny bug I had never heard of and couldn’t see. A drug-resistant staph infection called methicillin-resistant Staphylococcus aureus cost me my NFL career—and almost my life. MRSA is one of many deadly, antibiotic-resistant infections. Together, these “superbugs” k...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized health Source Type: news
In this study, we investigated the molecular epidemiology of nine carbapenemase-producing K. pneumoniae isolates from a local hospital in Shanghai, China. All strain isolates belong to sequence type 11 (ST11) and harbor the blaKPC-2 gene. The S1-PFGE (S1 nuclease pulsed field gel electrophoresis) pattern of the isolates did not show any relationship to the multilocus sequence typing (MLST) profiles. In addition, we characterized phage 117 and phage 31 and assessed the potential application of phage therapy in treating K. pneumoniae infections in vitro. The results of morphological and genomic analyses suggested that both p...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
Title: Fetroja Approved to Treat Complicated Urinary Tract InfectionsCategory: Health NewsCreated: 11/16/2019 12:00:00 AMLast Editorial Review: 11/18/2019 12:00:00 AM
Source: MedicineNet Womens Health General - Category: OBGYN Source Type: news
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
To evaluate how previous antimicrobial resistance, prior prescription data and patient place of residence (ZIP code) can guide empiric therapy for uncomplicated urinary tract infections (UTI).Guidelines recommend empiric antimicrobial selection for women with symptoms of uncomplicated UTIs, most commonly trimethoprim-sulfamethoxazole (SXT), nitrofurantoin (NIT) or ciprofloxacin (CIP). Previous antimicrobial resistance and prior prescription data are potential predictors of resistance in subsequent urine cultures for UTIs.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
In conclusion, limited evidence shows that routine urodynamics prior to non-surgical management of UI or surgical management of SUI is not associated with improved treatment outcomes, when compared to clinical evaluation only. Well-designed clinical trials are needed to evaluate the clinical and cost-effectiveness of routine urodynamics prior to surgical management of SUI and OAB.
Source: European Journal of Obstetrics and Gynecology and Reproductive Biology - Category: OBGYN Source Type: research
Publication date: Available online 14 November 2019Source: The LancetAuthor(s): Michel Attal, Paul G Richardson, S Vincent Rajkumar, Jesus San-Miguel, Meral Beksac, Ivan Spicka, Xavier Leleu, Fredrik Schjesvold, Philippe Moreau, Meletios A Dimopoulos, Jeffrey Shang-Yi Huang, Jiri Minarik, Michele Cavo, H Miles Prince, Sandrine Macé, Kathryn P Corzo, Frank Campana, Solenn Le-Guennec, Franck Dubin, Kenneth C AndersonSummaryBackgroundIsatuximab is a monoclonal antibody that binds a specific epitope on the human CD38 receptor and has antitumour activity via multiple mechanisms of action. In a previous phase 1b study, ar...
Source: The Lancet - Category: General Medicine Source Type: research
FRIDAY, Nov. 15, 2019 -- Antibacterial drug Fetroja (cefiderocol) has been approved to treat patients aged 18 years and older with complicated urinary tract infections (cUTIs), the U.S. Food and Drug Administration announced yesterday. The drug is...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
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