FGD5 marks a subpopulation of HSPCs that resists IFN- γ-mediated differentiation

The hematopoietic system is comprised of dozens of cell types starting from the most primitive hematopoietic stem cells (HSCs) to terminally differentiated lineage cells 1. Even within canonically defined populations, one can find heterogeneity in gene expression and function 2,3. While all hematopoietic trees are defined to start at a single population of HSCs, there is an accumulating compendium of evidence that shows how diverse HSCs can be, both in terms of function and gene expression 4 –9.

Source: Experimental Hematology - June 25, 2022 Category: Hematology Authors: Daniel E. Morales-Mantilla, Katherine Y. King Source Type: research