Novel Mycobacterium tuberculosis Complex Genotype Related to M. caprae

We report the unusual genotypic characterization of a bacterium isolated from a clinical sample of a patient who grew up in Bangladesh and lives in the United States. Using whole-genome sequencing, we identified the bacterium as a member of the Mycobacterium tuberculosis complex (MTBC). Phylogenetic placement of this strain suggests a new MTBC genotype. Even though it had the same spoligotype as M. caprae strains, single-nucleotide polymorphism-based phylogenetic analysis placed the isolate as a sister lineage distinct from M. caprae, most closely related to 5 previously sequenced genomes isolated from primates and elephants in Asia. We propose a new animal-associated lineage, La4, within MTBC.PMID:35731170 | DOI:10.3201/eid2807.212353

Source: Emerging Infectious Diseases - June 22, 2022 Category: Infectious Diseases Authors: Joseph Shea Carol Smith Tanya A Halse Donna Kohlerschmidt Amy K Rourke Kimberlee A Musser Vincent Escuyer Pascal Lapierre Source Type: research