Deletion C-terminal thioesterase abolishes melanin biosynthesis, affects metabolism and reduces the pathogenesis of < i > Fonsecaea monophora < /i >

In conclusion, we confirmed the crucial role of C-terminal TE in maintaining fully function ofpks1 inF.monophora. Deletion of TE negatively impacts on the synthesis of melanin and metabolites that eventually affect growth and virulence ofF.monophora. Any potential inhibitor of TE then could be a novel antifungal target for drug development.

Source: PLoS Neglected Tropical Diseases - June 13, 2022 Category: Tropical Medicine Authors: Minying Li Source Type: research