Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity

Most non-reproductive human cancers exhibit sex differences, but the underlying immunological mechanism remains unknown. Yang et  al. identify that AR signaling accelerates the transition from stem cell-like CD8+ T cells to terminally exhausted CD8+ T cells in males, leading to sex-biased antitumor immunity, whereas AR signaling inhibition reprograms CD8+ T cells into a stem cell-like state to potentiate cancer immunother apy.

Source: Immunity - June 13, 2022 Category: Allergy & Immunology Authors: Chao Yang, Jingsi Jin, Yuanqin Yang, Hongxiang Sun, Lingling Wu, Mingyi Shen, Xiaochuan Hong, Wenwen Li, Lu Lu, Dongqing Cao, Xinran Wang, Jing Sun, Youqiong Ye, Bing Su, Liufu Deng Tags: Article Source Type: research