Local Therapies for Colorectal Cancer Oligometastases to the Lung

AbstractPurpose of ReviewThere is a growing consensus that oligometastatic disease-directed treatment is associated with improved oncologic outcomes in patients with colorectal cancer; however,the optimal local management of pulmonary oligometastases remains controversial.Recent FindingsWhile surgery has traditionally been recognized as the gold standard local treatment for pulmonary metastases, there is no prospective data supporting a significant benefit of pulmonary metastasectomy (PME) compared to other local treatment modalities, such as stereotactic ablative radiotherapy (SABR) or radiofrequency ablation (RFA). There has been increasing utilization of SABR for pulmonary oligometastases —particularly for patients who are not candidates for PME, with comparable survival, local control, and toxicity observed.SummaryThere remains an unmet need for high-quality prospective data to optimally guide patient selection for local treatment modalities of pulmonary oligometastases. Given the evolving complexity of oligometastatic disease states and multitude of local and systemic treatment factors, multidisciplinary clinical discussion is essential.
Source: Current Colorectal Cancer Reports - Category: Cancer & Oncology Source Type: research