Which chemotherapeutic agent is well known to cause coronary vasospasm?
5-fluorouracil is well known to cause coronary vasospasm. 5-fluorouracil and its orally active prodrug capecitabine are fluoropyrimidines, belonging to the class of antimetabolites used for treatment of malignancies of breast, head and neck tumours and gastrointestinal tumours.
Mechanisms for coronary vasospasm
Endothelial cell damage with cytolysis and denudation
Increased endothelin-1 bioactivity leading to vasoconstriction
When high dose infusions are given, coronary vasospasm with angina, arrhythmia or even sudden death can occur in up to 5% of patients. Vascular toxicity occurs generally within 72 hours of the...
Source: Cardiophile MD - November 13, 2022 Category: Cardiology Authors: Johnson Francis Tags: General Cardiology Source Type: blogs
Chemotherapeutic agent causing coronary vasospasm – Cardiology MCQ – Answer
Chemotherapeutic agent causing coronary vasospasm – Cardiology MCQ – Answer
Chemotherapeutic agent well known to cause coronary vasospasm:Correct answer: c) 5-fluorouracil
5-fluorouracil and its orally active prodrug capecitabine are fluoropyrimidines, belonging to the class of antimetabolites used for treatment of malignancies of breast, head and neck tumours and gastrointestinal tumours.
Mechanisms for coronary vasospasm
Endothelial cell damage with cytolysis and denudation
Increased endothelin-1 bioactivity leading to vasoconstriction
When high dose infusions are given, coronary vasospasm with angina, arrh...
Source: Cardiophile MD - February 22, 2019 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology MCQ DM / DNB Cardiology Entrance Source Type: blogs
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An update from Tim:Here are the last few Facebook posts I made on Laurie ' s behalf over the last few months. Apologies for everyone who is not on Facebook or connected with me by email.November 16I would like to let you all know how Laurie is doing and what is going on health wise with her.Over the last few weeks Laurie has been suffering from some cognitive issues that has limited her ability to post and comment here, As these issues got more serious her oncologist scheduled an MRI to try and find out the cause and to make a plan to deal with it. The MRI showed that there are new tumours in her brain. I have not read&nbs...
Source: Not just about cancer - January 8, 2018 Category: Cancer & Oncology Source Type: blogs
MKSAP: 58-year-old man with cancer of the ascending colon
Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians.
A 58-year-old man undergoes follow-up evaluation for cancer of the ascending colon diagnosed 3 weeks ago. Colonoscopy at that time revealed a fungating mass in the ascending colon. Biopsy revealed adenocarcinoma, and additional studies showed no evidence of metastatic disease. Right hemicolectomy was performed. The pathology report showed a 4-cm primary adenocarcinoma with clear margins at resection, full-thickness penetration through the colonic wall into pericolonic fat, and 4/21 lymph nodes involved (stage II...
Source: Kevin, M.D. - Medical Weblog - August 26, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/mksap" rel="tag" > mksap < /a > Tags: Conditions Gastroenterology Oncology/Hematology Source Type: blogs
A Year in Review: FDA 2015 New Drug Approvals
The approval of first-of-a-kind drugs rose last year to forty-one, resulting in the highest level of newly approved U.S. drugs in nineteen years. The total number of new drugs approved last year was even higher at sixty-nine. The rising figures reflect an industry-wide desire to research and develop drugs for rare and hard-to-treat diseases.
The newly approved drugs serve to advance medical care and the health of patients suffering from many ailments, including various forms of cancer, heart failure, and cystic fibrosis. Additionally, more than 40% of the new therapies were approved for treatment of rare or "orphan" dise...
Source: Policy and Medicine - January 13, 2016 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
Funtabulously Frivolous Friday Five 119
Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia…introducing Funtabulously Frivolous Friday Five 119
Question 1
Which surgeon had a mortality rate of 300% during a single operation? How did this happen?
+ Reveal the Funtabulous Answer
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Robert Liston (1794-1847)
Liston operated in a time before anaesthesia. It was recognised that a speedy operation could significantly improve the outcomes for a patient, and Mr Liston w...
Source: Life in the Fast Lane - October 2, 2015 Category: Emergency Medicine Authors: Niall Hamilton Tags: Frivolous Friday Five capecitabine ciguatera FFFF louis pasteur Oncology rabies robert liston virchow Source Type: blogs
New nanopharmaceutical may help overcome resistance to specific anticancer drugs
Conclusions: Results generated through this translational research plan suggest that CRLX101 can overcome HIF-1α-mediated acquired resistance to antiangiogenic drugs, assisting the use of CRLX101 in combination with antiangiogenic medicines as an exciting new paradigm for the treatment of cancer.
Related Posts:Cleveland Clinic’s preventive breast cancer vaccine…Harvard Stem Cell Institute publishes initial clinical trialImportant advance in the fight against skin cancerNew IBS treatment shows possible in Phase 2 researchNew blood test could help millions of patients with&hellip...
Source: My Irritable Bowel Syndrome Story - October 21, 2013 Category: Other Conditions Authors: Ken Tags: IBS News Source Type: blogs
Pharmalot... Pharmalittle... Good Morning
Rise and shine, everyone. Another sunny day is on the way. Moreover, we are graced with a deliciously cool breeze this morning, as well. All in all, a lovely atmosphere for attacking the workload, yes? So no need to delay. Grab a cup of something stimulating, reach for your to-do list and make a good effort. Meanwhile, here are a few tidbits to start you off. Have a swell day and do stay in touch...
Dementia Drugs Do Not Help Mild Cognitive Impairment (MedPage Today)
UK Docs Warned Of Hemophilia Risk With Sanofi's Plavix (Pharma Times)
Chiesi To Buy Rest Of Cornerstone Therapeutics (Reuters)
EU Approves Sanofi MS Drug Lemt...
Source: Pharmalot - September 17, 2013 Category: Pharma Commentators Authors: esilverman Source Type: blogs
Rich pharma companies, poor patients.
Pharmaceutical companies are getting rich on the backs of their patients. Don't believe me? Here's some proof.First we have an article from New Jersey on how Roche's profits are up 10% and its revenues are up 4% on profits from its breast cancer drugs. The company is now focusing on cancer drugs and hopes to find more high profit drugs as generics come available for drugs such as Herceptin. By the way, their cancer drugs cost between $70,000 and $100,000+ annually per patient.If you ask a pharma company you get the standard lines: 'no one pays those prices', 'they are covered by insurance', 'we do have programs for ...
Source: Caroline's Breast Cancer Blog - July 28, 2013 Category: Cancer Tags: patient rights medication costs Source Type: blogs
Top stories in health and medicine, January 30, 2013
This series is brought to you by MedPage Today.1. Some SSRIs Tied to Heart Rhythm Problems. Citalopram and two other antidepressants were associated with prolongation of corrected QT interval — a marker of increased ventricular arrhythmia risk.2. RUC Targeted at Senate Hearing on Primary Care. The nation’s primary care physician (PCP) shortage might be eased by requiring more transparency from the group that helps set Medicare pay rates.3. Combo Therapy Shines in Colon Cancer. First-line combination bevacizumab and capecitabine therapy may be an optimal first-line treatment for metastatic colorectal cancer in t...
Source: Kevin, M.D. - Medical Weblog - January 30, 2013 Category: Family Physicians Tags: Meds Cancer Heart Psychiatry Source Type: blogs
Successful colon cancer treatment
Jim’s son successful colon cancer treatment includes colon cancer chemotherapy – Oxaliplatin & Xeloda – and alternative cancer treatments given by a family member practitioner: an oncology nurse with an Msc. in cancer nursing. Stage iv colon cancer Jim’s son has stage iv colon cancer spread to liver and lungs, a loving […] (Source: Metastatic liver cancer)
Source: Metastatic liver cancer - February 4, 2009 Category: Cancer Authors: Kim Tags: Jim's son metastatic liver cancer survivor CANCER TREATMENT Colon Cancer colon cancer treatment oxaliplatin secondary liver cancer. cancer treatment options stage iv colon cancer xeloda Source Type: blogs
