FORWARDS-1: an adaptive, single-blind, placebo-controlled ascending dose study of acute baclofen on safety parameters in opioid dependence during methadone-maintenance treatment —a pharmacokinetic-pharmacodynamic study
This study aims to understand whether there are any safety issues in administering baclofen to opioid-dependent individuals receiving methadone.MethodsOpiate-dependent individuals (DSM-5 severe opioid use disorder) maintained on methadone will be recruited from addiction services in northwest London (NHS and third sector providers). Participants will be medically healthy with no severe chronic obstructive pulmonary disease or type 2 respiratory failure, no current dependence on other substances (excluding nicotine), no current severe DSM-5 psychiatric disorders, and no contraindications for baclofen or 4800 IU vitamin D (p...
Source: Trials - October 18, 2022 Category: Research Source Type: clinical trials
Evaluation of the Modified Early Warning Scoring System
Conditions: Clinical Deterioration; Postoperative Complications; Nurse's Role Intervention: Other: MEWSS and Nursing Guide Application Sponsor: Kocaeli University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 12, 2022 Category: Research Source Type: clinical trials
Eligibility screening older research participants using remote cognitive assessment —experiences and reflections from a primary care randomised controlled trial
ConclusionThe MoCA is a useful tool when cognitive impairment is part of screening and data collection and it is helpful to have the option to use the test remotely. However, as we have found, telephone testing is not always straightforward. Researchers should weigh up the pros and cons for each individual study, especially those involving older adults. If choosing remote methods, consider the practicality of using videoconferencing and think about the possible impact of telephone assessment on the relationship with the (potential) research participants.Trial registrationPersonalised care planning for older people with fra...
Source: Trials - October 8, 2022 Category: Research Source Type: clinical trials
Evaluation of a Beverage Media Campaign and Added-sugar Warning Labels
Conditions: Attitude; Intention Interventions: Behavioral: Control bar code label; Behavioral: Warning label; Behavioral: Informational campaign poster about added-sugar warning labels Sponsor: University of California, Davis Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - October 3, 2022 Category: Research Source Type: clinical trials
