Randomized double-blind, placebo-controlled study of topical diclofenac in the prevention of hand-foot syndrome in patients receiving capecitabine (the D-TORCH study)
In this study, we aim to compare topical 1% diclofenac gel with placebo in the prevention of capecitabine-induced HFS.MethodsThis is a randomized, placebo-controlled, double-blind, parallel-group superiority trial: the Diclofenac Topical in Reducing Capecitabine induced HFS (D-TORCH) study. A total of 264 patients with breast and gastrointestinal malignancies will be randomly allocated (stratified by sex and type of therapy [monotherapy or combination regimen with capecitabine]) to receive either 1% topical diclofenac or placebo that will be applied over the palmar and dorsal surface of the hands twice daily whilst taking ...
Source: Trials - May 19, 2022 Category: Research Source Type: clinical trials
Efficacy and safety of Tibetan medicine Qingpeng ointment for acute gouty arthritis: protocol for a multi-center, randomized, double-blind, placebo-controlled trial
This study is designed as a multi-center, randomized, double-blind, placebo-controlled trial. Two hundred and six adults with acute flare of gout, and visual analogue scale (VAS) score of joint pain ≥ 3 points will be recruited. Participants will be randomly assigned to herbal treatment or placebo group at a ratio of 1:1. Qingpeng ointment, or equal placebo ointment, will be applied topically at involved joints twice a day for consecutive 7 days. Patients in both groups would be allowed givin g diclofenac sodium sustained-release tablets as rescue therapy when VAS score of joint pain ≥ 7 points during the treatment. Th...
Source: Trials - May 12, 2022 Category: Research Source Type: clinical trials
Efficiency and Safety a Fixed Combination of Orphenadrine and Diclofenac for Postoperative Analgesia
Condition: Analgesia Interventions: Drug: Analgesics Non Opioid (Neodolpasse manufactured by Fresenius Kabi); Drug: Analgesics Sponsor: Petrovsky National Research Centre of Surgery Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 12, 2022 Category: Research Source Type: clinical trials
Diclofenac Gel in the Treatment of Cervicogenic Headache
Condition: Cervicogenic Headache Interventions: Drug: Diclofenac 1% Topical; Other: Petroleum Jelly Sponsor: Loma Linda University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 5, 2022 Category: Research Source Type: clinical trials
