In Silico Models for Drug Resistance
We present two in silico models for the discovery of drug resistance mechanisms and for combating the evolution of resistance, respectively. In the first model, we computationally investigated subgraphs of a biological interaction network that show substantial adaptations when cells transcriptionally respond to a changing environment or treatment. As a case study, we investigated the response of the malaria parasite Plasmodium falciparum to chloroquine and tetracycline treatments. The second model involves a machine learning technique that combines clustering, common distance similarity measurements, and hierarchical clust...
Source: Springer protocols feed by Pharmacology/Toxicology - April 13, 2013 Category: Drugs & Pharmacology Source Type: news
tetracycline, Sumycin (Discontinued)
Title: tetracycline, Sumycin (Discontinued)Category: MedicationsCreated: 3/26/1998 2:30:00 PMLast Editorial Review: 4/4/2013 12:00:00 AM (Source: MedicineNet Hepatitis C General)
Source: MedicineNet Hepatitis C General - April 4, 2013 Category: Infectious Diseases Source Type: news
Environmental Engineers Seek Strategy To Control Antibiotic Resistant Genes
Rice University researchers "cured" a strain of bacteria of its ability to resist an antibiotic in an experiment that has implications for a long-standing public health crisis. Rice environmental engineer Pedro Alvarez and his team managed to remove the ability of the Pseudomonas aeruginosa microorganism to resist the antibiotic medication tetracycline by limiting its access to food and oxygen... (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 13, 2013 Category: Consumer Health News Tags: MRSA / Drug Resistance Source Type: news
Antibiotic-resistant diseases pose 'apocalyptic' threat, top expert says
Chief medical officer Dame Sally Davies tells MPs issue should be added to national risk register of civil emergenciesBritain's most senior medical adviser has warned MPs that the rise in drug-resistant diseases could trigger a national emergency comparable to a catastrophic terrorist attack, pandemic flu or major coastal flooding.Dame Sally Davies, the chief medical officer, said the threat from infections that are resistant to frontline antibiotics was so serious that the issue should be added to the government's national risk register of civil emergencies.She described what she called an "apocalyptic scenario" where peo...
Source: Guardian Unlimited Science - January 24, 2013 Category: Science Authors: Ian Sample Tags: The Guardian News Health Medical research Health policy Society Politics Antibiotics UK news Drug resistance Science Source Type: news
Identification of Pathogenetically Relevant Genes in Lymphomagenesis by shRNA Library Screens
RNA interference (RNAi) is a conserved posttranscriptional gene silencing mechanism that has recently emerged as a breakthrough genetic tool in functional genomics and drug target discovery. An increasing number of studies applying RNAi in high-throughput screens have begun to unravel complex signaling networks underlying diverse cellular processes. This chapter describes an approach to construct a conditional small-hairpin (sh)RNA library and its application in human lymphoma cell lines. A library cloning procedure outlines the incorporation of shRNA sequences and random 60-mer “bar code” oligonucleotides, ena...
Source: Springer protocols feed by Cancer Research - January 11, 2013 Category: Cancer & Oncology Source Type: news
Cholera and Diarrhea
CHOLERA and DIARRHEA
At this very moment there is an outbreak of cholera in Zimbabwe– not a worldwide pandemic, but a localized epidemic. This is not a trivial point of interest, but a major news event that will not only have a dramatic impact on the population of Zimbabwe but also on the entire world as the aftermath of this epidemic will require international aid. Cholera will most likely kill thousands of people in Zimbabwe, impact tens of thousands of lives, and will continue to be a constant threat around the world and a very real concern for the adventurous and international travelers.
What is cholera?
Cholera...
Source: Wilderness Medicine Newsletter - January 1, 2009 Category: Rural Health Authors: wildernessmedicinenewsletter Tags: Cholera Diarrhea Source Type: news
