Effect of Heroin Use on Immune Activation and Cardiovascular Risk in HIV
Conditions:   HIV Infection;   Opioid-use Disorder;   Cardiovascular Diseases Interventions:   Drug: buprenorphine/naloxone;   Drug: Methadone;   Drug: Naltrexone Injection;   Drug: Heroin Sponsors:   MetroHealth Medical Center;   National Institute on Drug Abuse (NIDA) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 5, 2019 Category: Research Source Type: clinical trials

Measures to Improve Outcomes After an Opioid Overdose
Condition:   Opioid Overdose Intervention:   Drug: Buprenorphine/Naloxone Sponsor:   Nassima Ait-Daoud Tiouririne Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - May 30, 2019 Category: Research Source Type: clinical trials

Rapid Initiation of Drug Treatment Engagement
Conditions:   Opioid-use Disorder;   Overdose Intervention:   Drug: buprenorphine/naloxone Sponsors:   University of Pennsylvania;   Prevention Point Philadelphia;   Public Health Management Corporation;   Philadelphia Department of Public Health Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 9, 2019 Category: Research Source Type: clinical trials

Incentivizing Buprenorphine-Naloxone Initiation in Emergency Departments
Condition:   Opioid Use Interventions:   Behavioral: Training;   Behavioral: Behavioral economic enhanced arm Sponsors:   University of Pennsylvania;   American College of Medical Toxicology;   Blue Cross Blue Shield Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - January 29, 2019 Category: Research Source Type: clinical trials

Single high-dose buprenorphine for opioid craving during withdrawal
The objective of this research is to evaluate the effect of a single, high dose of buprenorphine on craving in opioid-dependent patients over 5  days of abstinence from use of other opioids. The primary goal was to determine the safety and efficacy of buprenorphine during withdrawal in a hospital setting.MethodsNinety men who used opium, heroin, or prescribed opioids and met DSM-5 criteria for opioid use disorder (severe form) were randomized to three groups (n = 30 per group) to receive a single, sublingual dose of buprenorphine (32, 64, or 96 mg). The study was conducted in an inpatient psychi...
Source: Trials - December 10, 2018 Category: Research Source Type: clinical trials

Remote Observed Dosing of Suboxone to Improve Clinical Practice
Conditions:   Opioid-use Disorder;   Opioid Dependence;   Opiate Dependence Interventions:   Behavioral: Suboxone Remote Observed Dosing;   Other: Suboxone Attention Control Sponsor:   University of Pennsylvania Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - December 7, 2018 Category: Research Source Type: clinical trials