Reconvalescent plasma/camostat mesylate in early SARS-CoV-2 Q-PCR positive high-risk individuals (RES-Q-HR): a structured summary of a study protocol for a randomized controlled trial
This study is a 4-arm (parallel group), multicenter, randomized (2:2:1:1 ratio), partly double-blind, controlled trial to evaluate the safety and efficacy of convalescent plasma (CP) or camostat mesylate with control or placebo in adult patients diagnosed with SARS-CoV-2 infection and high risk for progression to moderate/severe COVID-19. Superiority of the intervention arms will be tested.ParticipantsThe trial is conducted at 10 –15 tertiary care centers in Germany. Individuals aged 18 years or above with ability to provide written informed consent with SARS-CoV-2 infection, confirmed by PCR within 3 days or less be...
Source: Trials - May 17, 2021 Category: Research Source Type: clinical trials
Post-operative Sore Throat and Gum Chewing
Conditions: Anesthesia; Surgery Interventions: Other: Gum; Other: Control Sponsor: University of Minnesota Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - April 26, 2021 Category: Research Source Type: clinical trials
Virtualized clinical studies to assess the natural history and impact of gut microbiome modulation in non-hospitalized patients with mild to moderate COVID-19 a randomized, open-label, prospective study with a parallel group study evaluating the physiologic effects of KB109 on gut microbiota structure and function: a structured summary of a study protocol for a randomized controlled study
This study is active and enrollment was completed in January, 2021.K032 protocol version 2, June 30, 2020; recruitment is estimated to start in July, 2020. This study is recruiting and the study is estimated to be completed in March 2021.Study registrationK031 is registered with the US National Library of Medicine, IdentifierNCT04414124 as of June 4, 2020.K032 is registered with the US National Library of Medicine, IdentifierNCT04486482 as of July 24, 2020.Full protocolThe full protocols are attached as additional files (Additional files1 and2), accessible from theClinicalTrials.gov website. In the interest in expediting d...
Source: Trials - April 2, 2021 Category: Research Source Type: clinical trials
Evaluation on immediate analgesic efficacy and safety of Kai-Hou-Jian spray (children ’s type) in treating sore throat caused by acute pharyngitis and tonsillitis in children: study protocol for a randomized controlled trial
DiscussionTo our knowledge, this will be the first clinical trial to explore the immediate analgesic efficacy of a Chinese patent medicine spray for acute pharyngitis/tonsillitis induced sore throat in children in a multicenter, randomized, double-blinded, parallel-group, placebo-controlled manner. Not only might it prove the efficacy and safety of KHJS in the treatment of sore throat caused by acute pharyngitis/tonsillitis in children, but it might also provide evidence for the treatment of acute sore throat with Chinese herbal medicine.Trial registrationA multicenter, randomized, double-blind, very low-dose, parallel con...
Source: Trials - March 18, 2021 Category: Research Source Type: clinical trials
