Exploring the effects of a combined exercise programme on pain and fatigue outcomes in people with systemic sclerosis: study protocol for a large European multi-centre randomised controlled trial
DiscussionData from this multi-centre research clinical trial will primarily be used to establish the effectiveness of a combined exercise protocol to improve pain and fatigue in SSc. In parallel, this study will be the first to explore the effects of long-term exercise on potential microvascular alterations assessed via NVC. Overall, this study will provide sufficient data to inform current clinical practice guidelines and may lead to an improvement of QoL for patients with SSc.Trial registrationClinicalTrials.gov NCT05234671. Registered on 14 January 2022 (Source: Trials)
Source: Trials - November 28, 2022 Category: Research Source Type: clinical trials
An Open-label Extension Trial of HZNP-HZN-825-301 in Adult Participants With Diffuse Cutaneous Systemic Sclerosis (Diffuse Cutaneous SSc)
Conditions: Diffuse Cutaneous Systemic Sclerosis; Sclerosis, Systemic Intervention: Drug: HZN-825 Sponsor: Horizon Pharma Ireland, Ltd., Dublin Ireland Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 25, 2022 Category: Research Source Type: clinical trials
Sleep Quality, Stress, Depression, Blood Pressure Responses to Diaphragmatic Respiratory Exercise in Systemic Sclerosis
Condition: Systemic Sclerosis Intervention: Behavioral: Tele-supervised diaphragmatic respiratory exercise Sponsor: Cairo University Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - November 21, 2022 Category: Research Source Type: clinical trials
