A hybrid digital parenting programme to prevent abuse of adolescents in Tanzania: study protocol for a pragmatic cluster-randomised controlled trial
This study aims to evaluate the effectiveness and cost-effectiveness of ParentApp compared to an attention-control group.MethodsThis study is a two-arm pragmatic cluster-randomised controlled trial to test whether ParentApp reduces adolescent physical abuse, emotional abuse, and sexual violence risks and victimisation at 1 month and 12 months post-intervention. Caregivers of adolescents aged 10–17 years and their adolescent children (N = 2400 caregiver-adolescent dyads) will be recruited in urban and peri-urban communities in the Mwanza region of Tanzania. A total of 80 study clusters will be stratified and rando...
Source: Trials - February 13, 2024 Category: Research Source Type: clinical trials
Effectiveness of a Multicomponent Intervention to Promote Physical Activity Levels During the School Day (MOVESCHOOL)
Conditions: Physical Activity; Adolescents; Physical Fitness; Cognition Interventions: Behavioral: Multicomponent school-based intervention. Sponsors: University of Extremadura; The Spanish Ministry of Science, Innovation and Universities Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 12, 2024 Category: Research Source Type: clinical trials
Rudi Kundini, Pamoja Kundini (RKPK): study protocol for a hybrid type 1 randomized effectiveness-implementation trial using data science and economic incentive strategies to strengthen the continuity of care among people living with HIV in Tanzania
DiscussionInnovative strategies that recognize the dynamic process of lifelong retention in HIV care are urgently needed. Strategies such as conditional economic incentives are a simple and effective method for improving many health outcomes, including those on the HIV continuum. If coupled with other supportive services such as home visits (phase 1) or with tailored counselling (phase 2), economic incentives have the potential to strengthen engagement among the subpopulation of PLHIV who struggle with retention in care and could help to close the gap towards reaching global “95–95-95” goals for ending the AIDS epide...
Source: Trials - February 10, 2024 Category: Research Source Type: clinical trials
Mosunetuzumab With Chemotherapy for the Treatment of Patients With Untreated C-Myc Rearrangement Positive High Grade B Cell Lymphoma or Diffuse Large B Cell Lymphoma
Conditions: Diffuse Large B-Cell Lymphoma; High Grade B-Cell Lymphoma Interventions: Procedure: Biopsy; Procedure: Biospecimen Collection; Procedure: Bone Marrow Aspiration and Biopsy; Procedure: Computed Tomography; Drug: Cyclophosphamide; Drug: Doxorubicin; Procedure: Echocardiography; Drug: Etoposide; Procedure: Magnetic Resonance Imaging; Biological: Mosunetuzumab; Procedure: Multigated Acquisition Scan; Procedure: Positron Emission Tomography; Drug: Prednisone; Drug: Vincristine Sponsors: OHSU Knight Cancer Institute; Genentech, Inc.; Oregon Health and Science University Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 8, 2024 Category: Research Source Type: clinical trials
A Phase 1b/2a, Study Evaluating the Safety, PK/PD and Efficacy of NS101 in Healthy Volunteers and SSNHL Patients
Conditions: Seneorineural Deafness; Sudden Sensorineural Hearing Loss Interventions: Biological: NS101; Biological: Placebo Sponsors: Neuracle Science Co., LTD.; Severance Hospital; Samsung Medical Center; Korea University Anam Hospital Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 8, 2024 Category: Research Source Type: clinical trials
Whole-Body Electrical Stimulation in Patients Undergoing Lung Transplantation
Conditions: Lung Transplantation; Electric Stimulation Interventions: Other: Whole-body electrical stimulation; Other: Routine physical therapy Sponsors: Federal University of Health Science of Porto Alegre; Irmandade Santa Casa de Miseric órdia de Porto Alegre Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 8, 2024 Category: Research Source Type: clinical trials
The Effect of Aerobic Exercise on Lower Urinary System Symptoms in Women With Diabetes Mellitus
Conditions: Lower Urinary Tract Symptoms; Diabetes Mellitus, Type 2 Interventions: Other: Aerobic Exercise; Behavioral: Behavioral Treatment Program Sponsors: Gaziantep Islam Science and Technology University; University of Gaziantep; Hasan Kalyoncu University Completed (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 8, 2024 Category: Research Source Type: clinical trials
The Prognostic Impact of Tumor Location in Non-Muscle-Invasive Bladder Cancer Patients
Conditions: Non-Muscle-Invasive Bladder Cancer; Bladder Cancer Interventions: Other: This was a retrospective study and no patient intervention was performed Sponsors: Huazhong University of Science and Technology Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 7, 2024 Category: Research Source Type: clinical trials
High-frequency Alternating Current Stimulation for Tremor in Parkinson's Disease.
Conditions: Parkinson ' s Disease and Parkinsonism; Nerve Block; Motor Activity Interventions: Device: Active group 10kHz; Device: Sham intervention Sponsors: University of Castilla-La Mancha; Ministry of science and innovation of Spain; Asociaci ón Parkinson Toledo (CAP Toledo) Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 7, 2024 Category: Research Source Type: clinical trials
Autism ALERT Expansion
Conditions: Autism Spectrum Disorder Interventions: Other: Autism ALERT Sponsors: Oregon Health and Science University; Providence Health& Services Active, not recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 7, 2024 Category: Research Source Type: clinical trials
Feasibility of a Positive Parenting Program for Women Experiencing Homelessness Who Have a History of Interpersonal Violence
Conditions: Interpersonal Violence; Homelessness Interventions: Behavioral: Positive Parenting Program; Behavioral: Usual Care Sponsors: The University of Texas Health Science Center, Houston; Rita and Alex Hillman Foundation - Hillman Emergent Innovation Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 7, 2024 Category: Research Source Type: clinical trials
Comparative Effectiveness of Two Initial Combination Therapies in Patients With Recent Onset Diabetes
Conditions: Type 2 Diabetes (Adult Onset) Interventions: Drug: Tirzepatide; Drug: Pioglitazone; Drug: Sitagliptin; Drug: Metformin HCI XR Sponsors: The University of Texas Health Science Center at San Antonio; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 7, 2024 Category: Research Source Type: clinical trials
Hyperpolarized 13C-MRI and Metabolomics for Immune-related Adverse Events
Conditions: Immune-related Adverse Event Interventions: Diagnostic Test: Hyperpolarized 13C-MRI Sponsors: Chang Gung Memorial Hospital; Ministry of Science and Technology, Taiwan Recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 6, 2024 Category: Research Source Type: clinical trials
The Sequencing for Detection in Congenital Heart Disease (SD-CHD) Study
Conditions: Congenital Heart Disease Interventions: Diagnostic Test: Whole Genome Sequencing (WGC) from subject samples Sponsors: Scripps Translational Science Institute Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - February 6, 2024 Category: Research Source Type: clinical trials
How many sites should an orthopedic trauma prospective multicenter trial have? A marginal analysis of the Major Extremity Trauma Research Consortium completed trials
ConclusionsOur data support that this model may be used by clinical researchers to achieve future study goals in a more cost-effective manner.Trial registrationPlease see Table 1 for individual trial registration numbers and dates of registration. (Source: Trials)
Source: Trials - February 5, 2024 Category: Research Source Type: clinical trials
