Mobile Point of Care Diagnostic Testing for Ebola Virus Disease in DRC
Conditions: Ebola Virus Disease (Ebola Virus) & Differentials; Malaria (Plasmodium Falciparum); Typhoid Fever (Salmonella Typhi/Salmonella Parathyphi); Dengue Fever (Dengue Virus); Chikunkunya Fever (Chikunkunya Virus); Yellow Fever (Yellow Fever Virus) Intervention: Diagnostic Test: Differential RPA tests Sponsors: University of Stirling; Institut National de Recherche Biomédicale. Kinshasa, République Démocratique du Congo; Institute Pasteur de Dakar, Senegal; University of Göttingen; Centre de Recheche du Centre Hospitalier Université Laval Not yet r...
Source: ClinicalTrials.gov - January 21, 2020 Category: Research Source Type: clinical trials
Typhoidal Salmonella human challenge studies: ethical and practical challenges and considerations for low-resource settings
AbstractTyphoidalSalmonella is a major global problem affecting more than 12 million people annually. Controlled human infection models (CHIMs) in high-resource settings have had an important role in accelerating the development of conjugate vaccines againstSalmonella Typhi.The typhoidalSalmonella model has an established safety profile in over 2000 volunteers in high-income settings, and trial protocols, with modification, could be readily transferred to new study sites. To date, a typhoidalSalmonella CHIM has not been conducted in a low-resource setting, although it is being considered.Our article describes the challenge...
Source: Trials - December 18, 2019 Category: Research Source Type: clinical trials
Salmonella Conjugates CVD 1000: Study of Responses to Vaccination With Trivalent Invasive Salmonella Disease Vaccine
Condition: Risk Reduction Interventions: Biological: Trivalent Invasive Salmonella Disease Vaccine (6.25 µg); Biological: Trivalent Invasive Salmonella Disease Vaccine (12 µg); Biological: Trivalent Invasive Salmonella Disease Vaccine (25 µg); Biological: Trivalent Invasive Salmonella Disease Vaccine (highest, well-tolerate d dose among Cohorts A-C); Other: Placebo Sponsor: University of Maryland Not yet recruiting (Source: ClinicalTrials.gov)
Source: ClinicalTrials.gov - June 11, 2019 Category: Research Source Type: clinical trials
