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The protective effect of bone marrow mesenchymal stem cells in a rat model of ischemic stroke via reducing the C-Jun N-terminal kinase expression.
Abstract Ischemic stroke is the main cause of disability and mortality worldwide. Apoptosis and inflammation have an important role in ischemic brain injury. Mesenchymal stem cells (MSCs) have protective effects on stroke treatment due to anti-inflammatory properties. The inhibition of the C-Jun N-terminal kinase (JNK) pathway may be one of the molecular mechanisms of the neuroprotective effect of MSCs in ischemic brain injury. Twenty-eight male Wistar rats were divided randomly into 3 groups. Except the sham group, others subjected to transient middle cerebral artery occlusion (tMCAO). Bone marrow MSCs or saline ...
Source: Pathology, Research and Practice - June 26, 2019 Category: Pathology Authors: Vahidinia Z, Azami Tameh A, Nejati M, Beyer C, Talaei SA, Etehadi Moghadam S, Atlasi MA Tags: Pathol Res Pract Source Type: research

The protective effect of bone marrow mesenchymal stem cells in a rat model of ischemic stroke via reducing the C-Jun N-terminal kinase expression
Publication date: Available online 27 June 2019Source: Pathology - Research and PracticeAuthor(s): Zeinab Vahidinia, Abolfazl Azami Tameh, Majid Nejati, Cordian Beyer, Sayyed Alireza Talaei, Sepideh Etehadi Moghadam, Mohammad Ali AtlasiAbstractIschemic stroke is the main cause of disability and mortality worldwide. Apoptosis and inflammation have an important role in ischemic brain injury. Mesenchymal stem cells (MSCs) have protective effects on stroke treatment due to anti-inflammatory properties. The inhibition of the C-Jun N-terminal kinase (JNK) pathway may be one of the molecular mechanisms of the neuroprotective effe...
Source: Pathology Research and Practice - June 28, 2019 Category: Pathology Source Type: research

Bone marrow stromal cells reverse the microglia type from pro-inflammatory tumour necrosis factor a microglia to anti-inflammatory CD206 microglia of middle cerebral artery occlusion rats through triggering secretion of CX3CL1
In conclusion, BMSCs reverse microglia from pro-inflammatory type TNF-a microglia to anti-inflammatory type CD206 microglia in the infarct region of MCAO rats (3rd to 7th days post BMSC transplantation), through triggering of CX3CL1 secretion. Therefore, the potential effects of CX3CL1 secreted by BMSCs would provide an insight for stem cell-dependent therapeutic strategies in treating ischaemic stroke-associated disorders.PMID:33969675 | DOI:10.5114/fn.2021.105129
Source: Folia Neuropathologica - May 10, 2021 Category: Pathology Authors: Xiu-Juan Bai Lei Hao Yan-E Guo Xiao-Bing Shi Wei-Ping Wu Source Type: research

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