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Enhanced recovery from chronic ischemic injury by bone marrow cells in a rat model of ischemic stroke.
This study provides valuable insights into the effect of BMC transplantation in the chronic ischemic brain, which lead to the development of effective therapy for chronic stroke patients who currently lack satisfactory therapeutic options. PMID: 24152766 [PubMed - as supplied by publisher]
Source: Cell Transplantation - October 22, 2013 Category: Cytology Authors: Yoo J, Seo JJ, Eom JH, Hwang DY Tags: Cell Transplant Source Type: research

Intranasal Delivery of Bone Marrow Mesenchymal Stem Cells Improved Neurovascular Regeneration and Rescued Neuropsychiatric Deficits after Neonatal Stroke in Rats.
Abstract Neonatal stroke is a major cause of mortality and long-term morbidity in infants and children. Currently very limited therapeutic strategies are available to protect the developing brain against ischemic damage and promote brain repairs for pediatric patients. Moreover, children who experienced neonatal stroke often have developmental social behavior problems. Cellular therapy using bone marrow mesenchymal stem cells (BMSCs) has emerged as a regenerative therapy after stroke. In the present investigation, neonatal stroke of postnatal day 7 (P7) rat pups was treated with non-invasive and brain specific int...
Source: Cell Transplantation - February 2, 2015 Category: Cytology Authors: Wei ZZ, Gu X, Ferdinand A, Lee JH, Ji X, Ji XM, Yu SP, Wei L Tags: Cell Transplant Source Type: research

Fibrinogen reduction and motor function improvement by hematopoietic growth factor treatment in chronic stroke in aged mice: a treatment frequency study.
This study provides new insight into understanding of the potential contribution of SCF+G-CSF in both reducing the risk of recurrent ischemic stroke and enhancing stroke recovery. PMID: 26817662 [PubMed - as supplied by publisher]
Source: Cell Transplantation - January 26, 2016 Category: Cytology Authors: Liu Y, Popescu M, Longo S, Gao M, Wang D, McGillis S, Zhao LR Tags: Cell Transplant Source Type: research

Transplanting Mesenchymal Stem Cells for Treatment of Ischemic Stroke.
Abstract Stroke is a major disease that leads to high mortality and morbidity. Given the ageing population and the potential risk factors, the prevalence of stroke and socioeconomic burden associated with stroke are expected to increase. During the past decade, both prophylactic and therapeutic strategies for stroke have made significant progress. However, current therapies still cannot adequately improve the outcomes of stroke and may not apply to all patients. One of the significant advances in modern medicine is cell-derived neurovascular regeneration and neuronal repair. Progress in stem cell biology has great...
Source: Cell Transplantation - September 25, 2018 Category: Cytology Authors: Wang F, Tang H, Zhu J, Zhang JH Tags: Cell Transplant Source Type: research

Stroke serum priming modulates characteristics of mesenchymal stromal cells by controlling the expression miRNA-20a.
Abstract Transplantation of mesenchymal stem cells (MSCs), expanded with fetal bovine serum (FBS), has some limitations, including a long culture period required to obtain sufficient stem cells. Priming of MSCs with serum from patients with ischemic stroke (stroke serum) increased the proliferation rate and the neurorestorative capacity of MSCs. We hypothesized that this novel priming method increases the proliferation rate of MSCs via the regulation of microRNAs (miRs). Thus, we investigated miR profiling in stroke serum primed MSCs and tested whether the regulation of certain miRs may affect the proliferation ra...
Source: Cell Transplantation - January 13, 2016 Category: Cytology Authors: Kim EH, Kim DH, Kim HR, Kim SY, Kim HH, Bang OY Tags: Cell Transplant Source Type: research

Therapeutic effect of ligustilide-stimulated adipose-derived stem cells in a mouse thromboembolic stroke model.
Abstract Stroke is a result of cerebral ischemia that triggers a cascade of both physiological and biochemical events. No effective treatment is available for stroke; however, stem cells have potential for use in rescue from the effects of stroke. Adipose-derived stem cells (ADSCs) are an abundant source of adult stem cells; therefore, ADSC therapy can be considered as a future strategy for regenerative medicine. However, more research is required to improve the effectiveness of transplanted ADSCs as a treatment for stroke in the mouse stroke model. Ligustilide isolated from the herb Angelica sinensis exhibits a n...
Source: Cell Transplantation - January 18, 2016 Category: Cytology Authors: Chi K, Fu RH, Huang YC, Chen SY, Lin SZ, Huang PC, Lin PC, Chang FK, Liu SP Tags: Cell Transplant Source Type: research

Breaking the blood brain barrier to aid stem cell therapeutics in the chronic stroke brain.
Abstract Blood brain barrier (BBB) permeabilizers, such as mannitol, can facilitate peripherally delivered stem cells to exert the therapeutic benefits on the stroke brain. Although this BBB permeation-aided stem cell therapy has been demonstrated in the acute stage of stroke, such BBB permeation in the chronic stage of the disease remains to be examined. Adult Sprague-Dawley rats initially received sham surgery or experimental stroke via the one-hour middle cerebral artery occlusion (MCAo) model. At one month after the MCAo surgery, stroke animals were randomly assigned to receive human umbilical cord stem cells ...
Source: Cell Transplantation - February 15, 2016 Category: Cytology Authors: Tajiri N, Lee JY, Acosta S, Sanberg PR, Borlongan CV Tags: Cell Transplant Source Type: research

Optogenetic Stimulation of Neural Grafts Enhances Neurotransmission and Downregulates the Inflammatory Response in Experimental Stroke Model.
Abstract Compelling evidence suggests that transplantation of neural stem cells (NSCs) from multiple sources ameliorates motor deficits after stroke. However, it is currently unknown to what extent the electrophysiological activity of grafted neural stem cell progeny participates in the improvement of motor deficits and whether excitatory phenotypes of the grafted cells are beneficial or deleterious to sensorimotor performances. To address this question, we used optogenetic tools to drive the excitatory outputs of the grafted NSCs and assess the impact on local circuitry and sensorimotor performance. We geneticall...
Source: Cell Transplantation - June 30, 2015 Category: Cytology Authors: Daadi MM, Klausner JQ, Bajar B, Goshen I, Lee-Messer C, Lee SY, Winge MC, Ramakrishnan C, Lo M, Sun G, Deisseroth K Tags: Cell Transplant Source Type: research

Novel therapeutic transplantation of induced neural stem cells for stroke.
In this study, we used a mouse model of transient middle cerebral artery occlusion (tMCAO). iNSCs (5 × 105) were injected directly into the ipsilateral striatum and cortex 24 hours after tMCAO. Histological analysis was performed at 7 days, 28 days, and 8 months after tMCAO. We found that iNSC transplantation successfully improved the survival rate of stroke model mice with significant functional recovery from the stroke. The fate of engrafted iNSCs was that the majority of iNSCs had differentiated into astroglial cells but not into neural cells in both the sham-operated brain and the post-stroke brain without forming a t...
Source: Cell Transplantation - September 19, 2016 Category: Cytology Authors: Yamashita T, Liu W, Matsumura Y, Miyagi R, Zhai Y, Kusaki M, Hishikawa N, Ohta Y, Kim SM, Kwak TH, Han DW, Abe K Tags: Cell Transplant Source Type: research

Label-Free Quantitative Proteome Profiling of Cerebrospinal Fluid from a Rat Stroke Model with Stem Cell Therapy
We examined hAMSC-secreted proteins obtained from serum-free culture medium by liquid chromatography-tandem mass spectrometry (LC-MS/MS), which identified several extracellular matrix proteins, supporting the well-known active paracrine function of hAMSCs. Subsequently, we performed label-free quantitative proteomic analysis on CSF samples from rat stroke models intravenously injected with hAMSC (experimental) or phosphate buffered saline (control). In total, 524 proteins were identified; among them, 125 and 91 proteins were increased and decreased with hAMSC treatment, respectively. Furthermore, gene set enrichment analys...
Source: Cell Transplantation - June 28, 2021 Category: Cytology Authors: Junseok W Hur Min-Sik Kim Se-Yeon Oh Ho-Young Kang Jingi Bae Hokeun Kim Hangyeore Lee Sang-Won Lee Dong-Hyuk Park Source Type: research

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