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Therapy: Stem Cell Therapy

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Total 59 results found since Jan 2013.

Sex differences in stroke therapies.
Abstract Stroke is the fifth leading cause of death and acquired disability in aged populations. Women are disproportionally affected by stroke, having a higher incidence and worse outcomes than men. Numerous preclinical studies have discovered novel therapies for the treatment of stroke, but almost all of these have been shown to be unsuccessful in clinical trials. Despite known sex differences in occurrence and severity of stroke, few preclinical or clinical therapeutics take into account possible sex differences in treatment. Reanalysis of data from studies of tissue plasminogen activator (tPA), the only curren...
Source: Cell Research - November 23, 2016 Category: Cytology Authors: Sohrabji F, Park MJ, Mahnke AH Tags: J Neurosci Res Source Type: research

Neural Stem Cells Therapy for Ischemic Stroke: Progress and Challenges
Transl Stroke Res. 2022 Jan 15. doi: 10.1007/s12975-022-00984-y. Online ahead of print.ABSTRACTIschemic stroke, with its high morbidity and mortality, is the most common cerebrovascular accident and results in severe neurological deficits. Despite advances in medical and surgical intervention, post-stroke therapies remain scarce, which seriously affects the quality of life of patients. Over the past decades, stem cell transplantation has been recognized as very promising therapy for neurological diseases. Neural stem cell (NSC) transplantation is the optimal choice for ischemic stroke as NSCs inherently reside in the brain...
Source: Cell Research - January 15, 2022 Category: Cytology Authors: Tong Zhao Tongming Zhu Liqian Xie Yao Li Rong Xie Feng Xu Hailiang Tang Jianhong Zhu Source Type: research

Endogenous Neural Stem Cell-induced Neurogenesis after Ischemic Stroke: Processes for Brain Repair and Perspectives
Transl Stroke Res. 2022 Sep 3. doi: 10.1007/s12975-022-01078-5. Online ahead of print.ABSTRACTIschemic stroke is a very common cerebrovascular accident that occurred in adults and causes higher risk of neural deficits. After ischemic stroke, patients are often left with severe neurological deficits. Therapeutic strategies for ischemic stroke might mitigate neuronal loss due to delayed neural cell death in the penumbra or seek to replace dead neural cells in the ischemic core. Currently, stem cell therapy is the most promising approach for inducing neurogenesis for neural repair after ischemic stroke. Stem cell treatments i...
Source: Cell Research - September 3, 2022 Category: Cytology Authors: Hailiang Tang Yao Li Weijun Tang Jianhong Zhu Graham C Parker John H Zhang Source Type: research

Mitochondrial transplantation and immune response of human bone marrow mesenchymal stem cells for the Therapeutic of ischemic stroke
Curr Stem Cell Res Ther. 2023 May 5. doi: 10.2174/1574888X18666230505103407. Online ahead of print.ABSTRACTIschemic stroke is the leading cause of death and disability worldwide, with increasing incidence and mortality, imposing a significant social and economic burden on patients and their families. However, cerebral vascular occlusion leads to acute loss of neurons and destruction of synaptic structures. The limited treatment options cannot adequately address intra-neuronal mitochondrial dysfunction due to stroke. Therefore, stem cell-derived mitochondria transplantation plays an important role in neuronal protection and...
Source: Cell Research - May 8, 2023 Category: Cytology Authors: Yidong Liao Jiang Ming Wenxue Song Guangtang Chen Junshuan Cui Longcai He Zili Wang Xudong Wang Mingsong Xiong Hua Yang Kaya Xu Source Type: research

Infarct-preconditioning exosomes of umbilical cord mesenchymal stem cells promoted vascular remodeling and neurological recovery after stroke in rats
CONCLUSIONS: Our results demonstrated that infarct-preconditioned exosomes promoted neurological recovery after stroke by enhancing vascular endothelial remodeling, suggested that infarct-preconditioned exosomes could be a novel way to alleviate brain damage following a stroke.PMID:35902882 | DOI:10.1186/s13287-022-03083-9
Source: Cell Research - July 28, 2022 Category: Cytology Authors: Yi-Chao Ye Zhe-Han Chang Peng Wang You-Wei Wang Jun Liang Chong Chen Jing-Jing Wang Hong-Tao Sun Yi Wang Xiao-Hong Li Source Type: research

GABAergic neurons differentiated from BDNF- and Dlx2-modified neural stem cells restore disrupted neural circuits in brainstem stroke
CONCLUSIONS: These findings demonstrated that BDNF- and Dlx2-modified NSCs differentiated into GABAergic neurons, integrated into and reconstituted the host neural networks, and alleviated the ischemic injury. It thus provided a potential therapeutic strategy for brainstem stroke.PMID:37365654 | DOI:10.1186/s13287-023-03378-5
Source: Cell Research - June 26, 2023 Category: Cytology Authors: Xiangyue Tang Li Wu Juehua Zhu Mindong Xu Shaojun Li Guanfeng Zeng Shuanggen Zhu Yongjun Jiang Source Type: research

Mesenchymal stem cell-derived exosomes for treatment of ischemic stroke
Curr Stem Cell Res Ther. 2021 Aug 12. doi: 10.2174/1574888X16666210812151003. Online ahead of print.ABSTRACTStroke is a life-threatening disease and one of the leading causes of death and physical disability worldwide. Currently, no drugs on the market promote neural recovery after stroke insult, and spontaneous remodeling processes are limited to induce recovery in the ischemic regions. Therefore, promoting a cell-based therapy has been needed to elevate the endogenous recovery process. Mesenchymal stem cells (MSCs) have been regarded as candidate cell sources for therapeutic purposes of ischemic stroke, which their thera...
Source: Cell Research - August 13, 2021 Category: Cytology Authors: Rucheng Liu Yi Zhang Yundi Zhang Maryam Farzaneh Seyed Esmaeil Khoshnam Source Type: research

Overexpression of vascular endothelial growth factor enhances the neuroprotective effects of bone marrow mesenchymal stem cell transplantation in ischemic stroke
Neural Regen Res. 2023 Jun;18(6):1286-1292. doi: 10.4103/1673-5374.358609.ABSTRACTAlthough bone marrow mesenchymal stem cells (BMSCs) might have therapeutic potency in ischemic stroke, the benefits are limited. The current study investigated the effects of BMSCs engineered to overexpress vascular endothelial growth factor (VEGF) on behavioral defects in a rat model of transient cerebral ischemia, which was induced by middle cerebral artery occlusion. VEGF-BMSCs or control grafts were injected into the left striatum of the infarcted hemisphere 24 hours after stroke. We found that compared with the stroke-only group and the ...
Source: Cell Research - December 1, 2022 Category: Cytology Authors: Cui Liu Zhi-Xiang Yang Si-Qi Zhou Ding Ding Yu-Ting Hu Hong-Ning Yang Dong Han Shu-Qun Hu Xue-Mei Zong Source Type: research

Exosome therapies improve outcome in rodents with ischemic stroke; Meta-analysis
This study systematically evaluated the efficacy of exosome therapy in ischemic stroke based on preclinical studies in rodent models.METHODS: We reviewed existing literature on exosome therapy in rodent stroke models from various databases, and reviewed the interventional measures, and outcome measures systematically, with changes in the infarct volume and functional scores as outcome parameters. Seventeen homogeneous studies were found qualitatively acceptable for meta-analysis. The study used software RevMan 5.3 to conduct the meta-analysis (PROSPERO Register Number: CRD42022314138) RESULTS: Compared to placebo, exosomes...
Source: Cell Research - January 2, 2023 Category: Cytology Authors: Simy Grace Cherian Sunil K Narayan Murugesan Arumugam Source Type: research

Functional reconstruction of the impaired cortex and motor function by hMGEOs transplantation in stroke
Biochem Biophys Res Commun. 2023 Jun 3;671:87-95. doi: 10.1016/j.bbrc.2023.06.010. Online ahead of print.ABSTRACTStroke is the leading cause of death and long-term disability worldwide. But treatments are not available to promote functional recovery, and efficient therapies need to be investigated. Stem cell-based therapies hold great promise as potential technologies to restore function in brain disorders. Loss of GABAergic interneurons after stroke may result in sensorimotor defects. Here, by transplanting human brain organoids resembling the MGE domain (human MGE organoids, hMGEOs) derived from human induced pluripotent...
Source: Cell Research - June 10, 2023 Category: Cytology Authors: Shi-Ying Cao Meng-Dan Tao Shu-Ning Lou Di Yang Yu-Hui Lin Hai-Yin Wu Lei Chang Chun-Xia Luo Yun Xu Yan Liu Dong-Ya Zhu Source Type: research

Combination of stem cell therapy and acupuncture to treat ischemic stroke: a prospective review
Stem Cell Res Ther. 2022 Mar 3;13(1):87. doi: 10.1186/s13287-022-02761-y.ABSTRACTStroke is the second leading cause globally that leads to severe disability and death. Stem cell therapy has been developed over the recent years to treat stroke and diminish the mortality and disability rate of brain injuries. Acupuncture, which can activate endogenous recovery via physical stimuli, has been applied to enhance the recovery and rehabilitation of stroke patients. Attempts have been made to combine stem cell therapy and acupuncture to treat stroke patients and have shown the promising results. This prospective review will look i...
Source: Cell Research - March 4, 2022 Category: Cytology Authors: Huidong Jia Jia He Lan Zhao Chia-Chen Hsu Xiaofeng Zhao Yuzheng Du Lin Han Zhanfeng Cui Xuemin Shi Hua Ye Source Type: research

Therapeutic potential of stem cell extracellular vesicles for ischemic stroke in preclinical rodent models: a meta-analysis
CONCLUSION: The present meta-analysis confirmed that SC-EV therapy could improve neuron function and reduce infarct volume in a preclinical rodent ischemic stroke model, providing helpful clues for human clinical trials on SC-EVs.PMID:37013588 | DOI:10.1186/s13287-023-03270-2
Source: Cell Research - April 4, 2023 Category: Cytology Authors: Jing Zhao Huiyin Deng Chengfeng Xun Chunli Chen Zhiping Hu Lite Ge Zheng Jiang Source Type: research

Stem Cell Implants: Emerging Innovation for Stroke Recovery
J Neuro Oncol Res. 2023;3(1):3102. Epub 2023 Apr 30.ABSTRACTStroke is a debilitating neurovascular injury that those effects hundreds of thousands of Americans each year. Despite the high prevalence, disease morbidity and mortality, options for stroke intervention and rehabilitation are still limited. Stem cells have shown promise in stroke treatment due to their ability to self-renew and differentiate into different cell types. The primary sources of stem cells used today are bone marrow and fetal brain tissue, with mesenchymal stem cells, bone marrow stem cells and neural stem cells being particularly well-studied. By se...
Source: Cell Research - May 25, 2023 Category: Cytology Authors: Reid Colliander Kaitlyn Alleman Michael Diaz Med Jimenez Patrick King Pranav Mirpuri Christopher Cutler Brandon Lucke-Wold Source Type: research

Preclinical Studies of Neural Stem/Progenitor Cell Therapy for Ischemic Stroke: A Systematic Review
CONCLUSION: Most of the preclinical studies reported statistically significant effects and very few adverse reactions. Transplantation of NSPCs for ischemic stroke still needs to be optimized for several key factors. A standardized treatment outcome assessment could ease the translation of evidence in clinical settings.PMID:35410620 | DOI:10.2174/1574888X17666220410221905
Source: Cell Research - April 12, 2022 Category: Cytology Authors: Mengze Zhang Kan Wang Chunran Xue Chong Xie Ze Wang Yaying Song Haojun Yu Yong Hao Yangtai Guan Source Type: research

Potential mechanisms and therapeutic targets of mesenchymal stem cell transplantation for ischemic stroke
This article reviewed biological characteristics, safety, feasibility and efficacy of MSCs therapy, potential therapeutic targets of MSCs, and production process of Good Manufacturing Practices-grade MSCs, to explore the potential therapeutic targets of MSCs in the process of production and use and provide new therapeutic directions for ischemic stroke.PMID:35551643 | DOI:10.1186/s13287-022-02876-2
Source: Cell Research - May 13, 2022 Category: Cytology Authors: Li Zhou Huimin Zhu Xue Bai Jiagui Huang Yue Chen Jun Wen Xuemei Li Bowen Wu Yongjun Tan Mingfen Tian Jiangxia Ren Mengxia Li Qin Yang Source Type: research