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Sexual and Gender Diversity in Pediatric Neurology: Why We Care
Sexual and gender diversity (SGD) – an inclusive term describing people who identify outside of heteronormative binary concepts of gender and sexuality – directly affects us in the pediatric neurology clinic. SGD identity can impact various neurological conditions, including headache, epilepsy, and functional neurological disord ers, all of which have been observed at higher rates in the SGD community.1-4 Gender-affirming hormone therapy can interact with medications commonly used to treat neurological conditions1,5,6 and may increase the risk for idiopathic intracranial hypertension7 and stroke.
Source: Pediatric Neurology - April 19, 2023 Category: Neurology Authors: Alison Christy, Jaclyn Martindale, Jennifer Hranilovich, Casey Orozco-Poore, Finley Kernan-Schloss, Chase T.M. Anderson, Jonathan Strober, Wendy Mitchell, Mackenzie P. Lerario Tags: Editorial Source Type: research

Sex and Gender Considerations in Episodic Migraine
AbstractPurpose of ReviewWe seek to update readers on recent advances in our understanding of sex and gender in episodic migraine with a two part series. In part 1, we examine migraine epidemiology in the context of sex and gender, differences in symptomatology, and the influence of sex hormones on migraine pathophysiology (including CGRP). In part 2, we focus on practical clinical considerations for sex and gender in episodic migraine by addressing menstrual migraine and the controversial topic of hormone-containing therapies. We make note of data applicable to gender minority populations, when available, and summarize kn...
Source: Current Pain and Headache Reports - June 9, 2022 Category: Neurology Source Type: research

Endocrine disorders in a patient with a suspicion of a mitochondrial disease, MELAS syndrome - a case report and literature review
We present a girl who was suspected of MELAS syndrome during the diagnostic evaluation of short stature. The patient suffered from symptoms potentially indicating mitochondrial disease, such as muscular weakness, cranial nerve VI palsy, headaches, retinitis pigmentosa, sensory-neural hearing loss, and elevated lactic acid. T2-weighted brain MRI showed hyperintense lesions in the white matter. Muscular biopsy revealed ragged red fibres. Genetic evaluation did not detect the most common mutations in the MT-TL1 gene and MT-ND5 gene. Endocrine tests led to the confirmation of growth hormone deficiency, and so replacement treat...
Source: Pediatric Endocrinology, Diabetes, and Metabolism - October 1, 2021 Category: Endocrinology Authors: Marta Baszy ńska-Wilk El żbieta Moszczyńska Maria Szarras-Czapnik Marta Wysocka-Mincewicz Urszula W ątrobińska Agata Koz łowska Mieczys ław Szalecki Source Type: research

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