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Flow Augmentation in Acute Ischemic Stroke
There is an urgent need for additional therapeutic options for acute ischemic stroke considering the major pitfalls of the options available. Herein, we briefly review the role of cerebral blood flow, collaterals, vasoreactivity, and reperfusion injury in acute ischemic stroke. Then, we reviewed pharmacological and interventional measures such as volume expansion and induced hypertension, intra-aortic balloon counterpulsation, partial aortic occlusion, extracranial–intracranial carotid bypass surgery, sphenopalatine ganglion stimulation, and transcranial laser therapy with regard to their effects on flow augmentation...
Source: Clinical and Applied Thrombosis/Hemostasis - December 9, 2015 Category: Hematology Authors: Yadollahikhales, G., Borhani-Haghighi, A., Torabi-Nami, M., Edgell, R., Cruz-Flores, S. Tags: Original Articles Source Type: research

Transcranial Laser Therapy in Acute Stroke Treatment: Results of Neurothera Effectiveness and Safety Trial 3, a Phase III Clinical End Point Device Trial Major Clinical Trial
Conclusions— Once the results of the interim futility analysis became available, all study support was immediately withdrawn by the capital firms behind PhotoThera, and the company was dissolved. Proper termination of the trial was difficult but was finally achieved through special efforts by former employees of PhotoThera, the CRO Parexel and members of the steering and the safety committees. We conclude that transcranial laser therapy does not have a measurable neuroprotective effect in patients with acute ischemic stroke when applied within 24 hours after stroke onset. Clinical Trial Registration— URL: http...
Source: Stroke - October 27, 2014 Category: Neurology Authors: Hacke, W., Schellinger, P. D., Albers, G. W., Bornstein, N. M., Dahlof, B. L., Fulton, R., Kasner, S. E., Shuaib, A., Richieri, S. P., Dilly, S. G., Zivin, J., Lees, K. R., for the NEST 3 Committees and Investigators, Broderick, Ivanova, Johnston, Norrvin Tags: Acute Cerebral Infarction Major Clinical Trial Source Type: research

Stroke: Transcranial laser therapy for stroke fails futility analysis
Nature Reviews Neurology 10, 611 (2014). doi:10.1038/nrneurol.2014.200 A phase III trial of transcranial laser therapy has been discontinued after an interim analysis found no effect of laser therapy on patients' disability after ischaemic stroke. The transcranial laser device used in the trial was purported to provide energy to hypoxic mitochondria via near-infrared
Source: Nature Reviews Neurology - October 21, 2014 Category: Neurology Tags: Research Highlight Source Type: research

Safety of tPA + Transcranial Emission of Low-Energy Lasers for Acute Stroke Recovery - Results (P4.219)
Conclusion: Transcranial Laser in this small exploratory study was well tolerated in combination with IV tPA. Larger studies are needed to explore if the combination of LASER therapy plus tPA is safe and shows better outcome than IV tPA alone.Study supported by NIH Grant P50 NS044148Clinical Trial Registry: NCT01220739Disclosure: Dr. Hemmen has nothing to disclose. Dr. Raman has nothing to disclose. Dr. Sen has received personal compensation for activities with Genentech Inc., Sanofi Aventis Pharmaceutical Inc., Bristol-Myers Squibb Co., and Boehringer Ingelheim Pharmaceuticals Inc. Dr. Sen has received research support fr...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Hemmen, T., Raman, R., Sen, S., Geraghty, M., Rapp, K., Richeri, S., Meyer, B., Zivin, J., Fanale, C. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Thrombolysis Source Type: research

Transcranial Laser Therapy and Infarct Volume Brief Reports
Conclusions— TLT was not associated with a reduction in overall or cortical infarct volume as measured on computed tomography in the subacute phase.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Kasner, S. E., Rose, D. Z., Skokan, A., Walker, M. G., Shi, J., Streeter, J., the NEST-2 Steering Committee and Investigators Tags: Acute Cerebral Infarction, Neuroprotectors Brief Reports Source Type: research