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Risk of Stroke After Definitive Radiotherapy —Cause for Concern or Modest Risk?
With the rapidly increasing prevalence of oropharyngeal squamous cell carcinoma (OPSCC), largely driven by the human papillomavirus (HPV) epidemic, and with relative equipoise between radiation-based and surgery-based treatment protocols, there has been renewed interest in describing differences in functional outcomes between the 2 treatment modalities. Radiation is theoretically related to stroke risk due to carotid artery intimal injury, which could lead to the development of atherosclerosis. Both carotid artery stenosis and carotid intima-medial thickness have been shown to be associated with radiation therapy providing...
Source: JAMA Otolaryngology - Head and Neck Surgery - June 23, 2022 Category: ENT & OMF Source Type: research

Surgical salvage of recurrent vestibular schwannoma following prior stereotactic radiosurgery
ConclusionMicrosurgical salvage of VS following primary radiation therapy is challenging. Less‐than‐complete resection is required in a greater percentage of patients to preserve facial nerve integrity and prevent neurological complications. Long‐term follow‐up is needed to determine the risk of delayed progression following incomplete tumor removal. Level of EvidenceLevel 3. Laryngoscope, 2016
Source: The Laryngoscope - April 22, 2016 Category: ENT & OMF Authors: Stephanie C. Wise, Matthew L. Carlson, Øystein Vesterli Tveiten, Colin L. Driscoll, Erling Myrseth, Morten Lund‐Johansen, Michael J. Link Tags: Otology/Neurotology Source Type: research

Microvascular free tissue reconstruction in the patient with multiple courses of radiation
ConclusionsMicrovascular free tissue transfer to the head and neck is expected to provide a successful reconstruction in patients who have received multiple courses of radiation and who develop second primary tumors, recurrence of disease, or who suffer from late complications of their radiation therapy. Level of Evidence4. Laryngoscope 124:2252–2256, 2014
Source: The Laryngoscope - May 2, 2014 Category: ENT & OMF Authors: Eli A. Gordin, Yadranko Ducic Tags: Facial Plastics and Reconstructive Surgery Source Type: research

Microvascular free tissue reconstruction in the multiply irradiated patient
Conclusion: Microvascular free tissue transfer to the head and neck is expected to provide a successful reconstruction in patients who have received multiple courses of radiation who develop second primary tumors, recurrence of disease, or who suffer from late complications of their radiation therapy.
Source: The Laryngoscope - March 20, 2014 Category: ENT & OMF Authors: Eli A. Gordin, Yadranko Ducic Tags: Original Report Source Type: research