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Aortic Root Dilatation in Hypertensive Patients with Left Ventricular Hypertrophy-Application of A New Multivariate Predictive Model. The Life Study
CONCLUSIONS: Using the proposed model the prevalence of AoR dilatation was equal in men and women and the model seems to address the effects of gender, age and body size on AoR size.CLINICAL TRIAL REGISTRATION: URL: https://www.CLINICALTRIALS: gov; Unique identifier: NCT00338260.PMID:35345262 | DOI:10.31083/j.rcm2303095
Source: Reviews in Cardiovascular Medicine - March 29, 2022 Category: Cardiology Authors: Alexander Lilja-Cyron Casper N Bang Eva Gerdts Anne C Larstorp Sverre E Kjeldsen Stevo Julius Peter M Okin Kristian Wachtell Richard B Devereux Source Type: research

Effects of Blood Pressure Lowering Agents on Cardiovascular Outcomes in Weight Excess Patients: A Systematic Review and Meta-analysis
ConclusionsIn hypertensive subjects with excess weight, diuretics are more effective for preventing HF and stroke than CCB and ACEI, respectively. CCB are a good first-line choice for prevention of cardiovascular disease, except HF.
Source: American Journal of Cardiovascular Drugs - January 2, 2020 Category: Cardiology Source Type: research

The effect of losartan therapy on ventricular function in Marfan patients with haploinsufficient or dominant negative FBN1 mutations.
CONCLUSION: Losartan therapy in haploinsufficient Marfan patients increases biventricular end diastolic volume and stroke volume, furthermore, losartan also appears to ameliorate biventricular filling properties. PMID: 27704402 [PubMed - as supplied by publisher]
Source: Netherlands Heart Journal - October 3, 2016 Category: Cardiology Authors: den Hartog AW, Franken R, van den Berg MP, Zwinderman AH, Timmermans J, Scholte AJ, de Waard V, Spijkerboer AM, Pals G, Mulder BJ, Groenink M Tags: Neth Heart J Source Type: research

Safety and Efficacy of Losartan/Hydrochlorothiazide Combination in Elderly Patients with Morning Hypertension: Mappy Study
Background: Cardiovascular events, such as stroke and myocardial infarction, occur most frequently in the morning. Morning hypertension is characteristic feature of hypertension in the elderly, and is attributed to hypertensive organ damage and cardiovascular events. However, treatment of morning hypertension has not been established, especially in the elderly patients. The aim of this study was to compare the safety and effectiveness between an an angiotensin II receptor blocker (ARB) / hydrochlorothiazide (HCTZ) combination therapy and high-dose ARB therapy in the elderly (75 years or more) and younger (less than 75 years) patients.
Source: Journal of Cardiac Failure - August 24, 2016 Category: Cardiology Authors: Hiroki Uchiwa, Hisashi Kai, Yoshiko Iwamoto, Takahiro Anegawa, Kenji Fukuda, Tsutomu Imaizumi, Yoshihiro Fukumoto Source Type: research

Electrocardiographic left atrial abnormalities and risk of incident stroke in hypertensive patients with electrocardiographic left ventricular hypertrophy
Conclusion: Abnormal PTFV1, a marker of left atrial abnormality, was strongly associated with incident stroke in hypertensive patients, independent of in-treatment SBP and other predictors of incident stroke. This association, in the absence of detectable atrial fibrillation, suggests that an underlying atrial cardiopathy may cause left atrial thrombus formation and a subsequent stroke without intervening clinically recognized atrial fibrillation.
Source: Journal of Hypertension - August 5, 2016 Category: Cardiology Tags: ORIGINAL PAPERS: Heart Source Type: research

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