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Po-01-140 atrial fibrillation and septic shock: a five-year retrospective observational study of anticoagulation usage, bleeding and stroke rates
Anticoagulation (AC) for atrial fibrillation (AF) is a cornerstone of management, and the benefit of mitigating stroke risk is accompanied by an increased risk of bleeding. The risk and benefit of AC in septic shock remains unclear as this disruptive hyperinflammatory state leads to multi-organ dysfunction, which can include coagulopathies.
Source: Heart Rhythm - May 1, 2023 Category: Cardiology Authors: Jonathan Na, Joanne Moon, Sahitya Allam, Maria Abraham, Kevin Chen, Ethan Kotloff, Yash Desai, Simin Hossain, Christopher Messner, Elnaz Esmati, Thomas Kutner, Gregory Norcross, James Childress, Paul Han, Ian Welch, Michael Sokolow, Libin Wang, Vincent Se Source Type: research

Dualistic roles and mechanistic insights of macrophage migration inhibitory factor in brain injury and neurodegenerative diseases
J Cereb Blood Flow Metab. 2022 Nov 11:271678X221138412. doi: 10.1177/0271678X221138412. Online ahead of print.ABSTRACTMacrophage migration inhibitory factor (MIF) is involved in various immune-mediated pathologies and regulates both innate and adaptive immune reactions, thus being related to several acute and chronic inflammatory diseases such as rheumatoid arthritis, septic shock, and atherosclerosis. Its role in acute and chronic brain pathologies, such as stroke and neurodegenerative diseases, has attracted increasing attention in recent years. In response to stimuli like hypoxia, inflammation or infection, different ce...
Source: Atherosclerosis - November 12, 2022 Category: Cardiology Authors: Wei Xuan Wanqing Xie Fengshi Li Dan Huang Ziyu Zhu Yuxuan Lin Binwei Lu Weifeng Yu Yan Li Peiying Li Source Type: research

Neurological Complications in Patients with Infective Endocarditis: Insights from a Tertiary Centre
Conclusions: In this population, embolization to the CNS was common, more often presented as ischemic stroke, and was associated with longer hospitalization, although without significant differences in mortality. In patients with CNS embolization, those submitted to surgery had a good clinical evolution, while patients with septic shock and HIV infection had a worse outcome. These results should be interpreted with caution, taking into consideration that patients with more severe complications or more fragile were probably less often considered for surgery, resulting in selection bias.
Source: Arquivos Brasileiros de Cardiologia - April 16, 2021 Category: Cardiology Source Type: research

Managing Patients with Infectious Endocarditis and Neurological Complication — The Big Dilemma that Persists Until these Days
Conclusions: In this population, embolization to the CNS was common, more often presented as ischemic stroke, and was associated with longer hospitalization, although without significant differences in mortality. In patients with CNS embolization, those submitted to surgery had a good clinical evolution, while patients with septic shock and HIV infection had a worse outcome. These results should be interpreted with caution, taking into consideration that patients with more severe complications or more fragile were probably less often considered for surgery, resulting in selection bias.
Source: Arquivos Brasileiros de Cardiologia - April 16, 2021 Category: Cardiology Source Type: research

Clinical outcomes in patients with native valve infective endocarditis and diabetes mellitus
CONCLUSION: There is an increasing prevalence of DM in NVIE and it is associated with poorer outcomes. Further studies are crucial to identify the clinical, and sociodemographic contributors to this trend and develop strategies to mitigate its attendant risk.PMID:33552399 | PMC:PMC7821010 | DOI:10.4330/wjc.v13.i1.11
Source: World Journal of Cardiology - February 8, 2021 Category: Cardiology Authors: Temidayo Abe Harry Onoriode Eyituoyo Gabrielle De Allie Titilope Olanipekun Valery Sammah Effoe Kikelomo Olaosebikan Paul Mather Source Type: research

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