• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Extreme preterm neonate with fetal warfarin syndrome
A 25+3 week gestation male infant weighing 493 g was delivered via caesarean section for intrauterine growth restriction and abnormal Dopplers. The mother was on long-term thromboprophylactic warfarin 5 mg/day due to her prosthetic mechanical heart valve following childhood rheumatic fever. Once pregnancy was diagnosed, at 4+0 weeks’ gestation, warfarin was discontinued and low-molecular-weight heparin was started. Warfarin was recommenced at 12+1 weeks’ gestation after a small maternal stroke. Neonatal dysmorphic facial features were noted, most obviously nasal hypoplasia (figure 1). The hypoplastic upper airw...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 19, 2023 Category: Perinatology & Neonatology Authors: Birbal, R., Olaniyi, O., Clarke, P. Tags: Images in neonatal medicine Source Type: research

Haemodynamic changes with varying chest compression rates in asphyxiated piglets
Conclusion Rate of CC was associated with changes in haemodynamic parameters during cardiopulmonary resuscitation. CC rate of 150–180/min during CC resulted in the highest cardiac output and arterial blood pressure. Trial registration number Preclincialtrials.eu PCTE0000249.
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 17, 2023 Category: Perinatology & Neonatology Authors: Bruckner, M., Neset, M., O'Reilly, M., Lee, T.-F., Cheung, P.-Y., Schmölzer, G. M. Tags: Short reports Source Type: research

Umbilical cord thrombosis and chorioamnionitis in neonatal arterial ischaemic stroke
A baby boy was delivered at term by emergency caesarean section because of abnormal fetal heart rate patterns during spontaneous labour. The umbilical cord arterial blood obtained at delivery had a pH of 6.97 and a lactate concentration of 12.1 mmol/L. The Apgar scores were 3 and 7, respectively, at 1 and 5 min. The proximal umbilical cord had a thrombotic aspect at delivery (figure 1). A thrombus was also identified in the ductus venosus at 1 hour of life. The boy presented left hemicorporeal seizures at 21 hours of life, which revealed a neonatal arterial ischaemic stroke (NAIS; figure 2). Placental histology revealed ac...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2022 Category: Perinatology & Neonatology Authors: Dridi, M., Chabrier, S., Raia-Barjat, T., Giraud, A. Tags: Open access Images in neonatal medicine Source Type: research

Impact of maternal obesity on neonatal heart rate and cardiac size
Conclusion Maternal obesity was associated with increased heart rate, decreased heart rate variability and decreased left ventricular volumes in newborns. If persistent, these changes may provide a causal mechanism for the increased cardiovascular risk in adult offspring of mothers with obesity. In turn, modifying antenatal and perinatal maternal health may have the potential to optimise long-term cardiovascular health in offspring.
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2022 Category: Perinatology & Neonatology Authors: Groves, A. M., Price, A. N., Russell-Webster, T., Jhaveri, S., Yang, Y., Battersby, E. E., Shahid, S., Costa Vieira, M., Hughes, E., Miller, F., Briley, A. L., Singh, C., Seed, P. T., Chowienczyk, P. J., Stern, K. W. D., Cohen, J., Pasupathy, D., Edwards, Tags: Original research Source Type: research

Diagnosis of hydrocephalus by cranial transillumination
A full-term neonate was examined to have significant macrocephaly (>>97th percentile), widened cranial sutures and a large bulging anterior fontanelle (AF). A light-emitting diode source applied on the AF revealed asymmetrical cranial transillumination, predominantly on the right (figure 1A). He was alert with spontaneous movements of all limbs but had generalised upper motor neuron (UMN) signs of hypertonia and hyper-reflexia. These signs indicated raised intracranial pressure from a possible right hemispheric cystic lesion. MRI showed a large right open-lip schizencephaly with encysted cerebrospinal fluid (CSF) tha...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2022 Category: Perinatology & Neonatology Authors: Lian, B. X., Ng, N. B. H., Wang, F., Nga, V. D. W., Tan, A. P., Lin, J. Tags: Images in neonatal medicine Source Type: research

Outcome of non-cooled asphyxiated infants with under-recognised or delayed-onset encephalopathy
Conclusions All infants with documented perinatal asphyxia and seizure onset within 24 hours after birth who did not receive TH had abnormalities on MRI. 51% had an adverse outcome. Better methods for recognition of infants who might benefit from TH and careful neurodevelopmental follow-up are urgently needed.
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 17, 2022 Category: Perinatology & Neonatology Authors: Parmentier, C. E. J., Steggerda, S. J., Weeke, L. C., Rijken, M., De Vries, L. S., Groenendaal, F. Tags: Original research Source Type: research

Neonatal arterial stroke location is associated with outcome at 2 years: a voxel-based lesion-symptom mapping study
Conclusions The identification of these susceptible brain areas will allow for more precise prediction of neurological impairments on the basis of neonatal brain MRI.
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - December 15, 2021 Category: Perinatology & Neonatology Authors: Nunez, C., Stephan-Otto, C., Arca, G., Agut, T., Arnaez, J., Cordeiro, M., Benavente-Fernandez, I., Boronat, N., Lubian-Lopez, S. P., Valverde, E., Hortigüela, M., Garcia-Alix, A. Tags: Original research Source Type: research

Upper extremity arterial thrombus presenting at birth
We report a 36-week neonate born to a 31-year-old G2P0 woman by emergency c-section due to decreased fetal movement. The pregnancy had been uncomplicated up to that point and the mother had no significant medical history. Birth weight was 2.49 kg. Apgars were 6 and 5. Superficial skin loss and dark blue discolouration were noted along the left upper extremity and hand immediately after delivery. Fluid resuscitation and sterile saline wraps slowly improved perfusion, and the extremity pinked up over the subsequent 3 h (figure 1). She was transferred to an appropriate outside facility where Doppler ultrasound revea...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 16, 2016 Category: Perinatology & Neonatology Authors: LaBore, B. P., Bedell, T. H. Tags: Journalology, Drugs: cardiovascular system, Stroke, Pregnancy, Reproductive medicine, Radiology, Clinical diagnostic tests, Radiology (diagnostics), Competing interests (ethics), Resuscitation, Trauma Images in neonatal medicine Source Type: research

Neonatal purpura fulminans due to protein C deficiency
A 3-day-old term male neonate born of third-degree consanguineous marriage was admitted with purplish black, oval tender lesions with erythematous rim on both soles and left hip. He was normothermic, haemodynamically stable and feeding well. However, new gangrenous lesions appeared on his fingers soon after admission. C-reactive protein was negative. Complete blood count revealed a platelet count of 73 000/mm3 with normal haematocrit and leucocyte count. Prothrombin time and activated partial thromboplastin time were prolonged (PT: 26 s; INR: 2.03; aPTT>100 s). Plasma protein C activity was detected to be...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - August 18, 2015 Category: Perinatology & Neonatology Authors: Sharma, S., Anbazhagan, J., Plakkal, N. Tags: Journalology, Genetic screening / counselling, Immunology (including allergy), Drugs: cardiovascular system, Stroke, Pregnancy, Reproductive medicine, Competing interests (ethics) Images in neonatal medicine Source Type: research

Serial cranial ultrasonography or early MRI for detecting preterm brain injury?
Conclusions Advanced serial CUS seems highly effective in diagnosing preterm brain injury, but may miss cerebellar abnormalities. Although MRI does identify these lesions, feasibility is limited. Improved safety, better availability and tailored procedures are essential for MRI to increase its value in clinical care.
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 19, 2015 Category: Perinatology & Neonatology Authors: Plaisier, A., Raets, M. M. A., Ecury-Goossen, G. M., Govaert, P., Feijen-Roon, M., Reiss, I. K. M., Smit, L. S., Lequin, M. H., Dudink, J. Tags: Epidemiologic studies, Neurological injury, Stroke, Child health, Radiology, Clinical diagnostic tests, Radiology (diagnostics), Trauma, Guidelines, Injury Original articles Source Type: research

Highlights from the literature
Morphine and the baby brain Morphine gets used a lot in neonatal care, especially as we now understand the need to give appropriate analgesia and sedation to babies receiving intensive care. Yet there has always been a nagging concern that though we do the right thing in early life, we may be creating difficulties for these babies in later childhood. We should take some reassurance about this from a paper by Steinhorn (J Pediatr 2015;166:1200–7) in which 230 babies, all under 30 weeks at birth and a quarter of whom received morphine, were followed up at 2 and 7 years. At 2 years the morphine exposed babies demonstrat...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - June 19, 2015 Category: Perinatology & Neonatology Tags: Clinical trials (epidemiology), Epidemiologic studies, Cerebral palsy, Epilepsy and seizures, Pain (neurology), Stroke, Child health, Neonatal and paediatric intensive care, Neonatal health, Pain (palliative care) Hyperion Source Type: research

Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial
Conclusions Maternal treatment with allopurinol during fetal hypoxia did not significantly lower neuronal damage markers in cord blood. Post hoc analysis revealed a potential beneficial treatment effect in girls. Trial registration number NCT00189007, Dutch Trial Register NTR1383.
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 17, 2015 Category: Perinatology & Neonatology Authors: Kaandorp, J. J., Benders, M. J. N. L., Schuit, E., Rademaker, C. M. A., Oudijk, M. A., Porath, M. M., Oetomo, S. B., Wouters, M. G. A. J., van Elburg, R. M., Franssen, M. T. M., Bos, A. F., de Haan, T. R., Boon, J., de Boer, I. P., Rijnders, R. J. P., Jac Tags: Clinical trials (epidemiology), Stroke Original articles Source Type: research

Quality of life in adulthood after resection of a sacrococcygeal teratoma in childhood: a Dutch multicentre study
Conclusions The long-term QoL of patients treated for SCT during childhood does not differ from that of the general population. Moreover, patients do not show impairment in social, physical or emotional functioning in adulthood.
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 17, 2015 Category: Perinatology & Neonatology Authors: Kremer, M. E. B., Dirix, M., Koeneman, M. M., van Baren, R., Heij, H. A., Wijnen, M. H. W. A., Wijnen, R. M. H., van der Zee, D. C., van Heurn, L. W. E. Tags: Oncology, Health policy, Stroke, Health service research Original articles Source Type: research

The BRACELET study: implications for the design of randomised controlled trials in neonatal and paediatric intensive care
Research is essential to improving care and outcomes, but presents challenges when infants and children are the patients. Over the last few years, several thousand infants and children receiving intensive care have joined randomised controlled trials (RCT) in the UK, the majority of those conducted under the auspices of the National Institute for Health Research (NIHR) portfolio. Globally, tens of thousands of children and infants take part in RCTs. When those children survive, many continue to partake in studies with involvement over several years and potentially into adulthood. That is essential; in no other branch of me...
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 18, 2015 Category: Perinatology & Neonatology Authors: Embleton, N. D., Rankin, J. Tags: Clinical trials (epidemiology), Stroke, Pregnancy, Reproductive medicine, Child health, Neonatal and paediatric intensive care, Neonatal health, Neonatal intensive care, Paediatric intensive care Editorials Source Type: research

Lactate, rather than ketones, may provide alternative cerebral fuel in hypoglycaemic newborns
Conclusions Hypoglycaemic babies within the first 48 h after birth are unlikely to receive neuroprotection from ketones. However, lactate may provide an alternative cerebral fuel for many. Lactate, rather than ketones, may provide alternative cerebral fuel in hypoglycaemic newborns. Trial registration number ACTRN12608000623392.
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 18, 2015 Category: Perinatology & Neonatology Authors: Harris, D. L., Weston, P. J., Harding, J. E. Tags: Stroke, Childhood nutrition, Reproductive medicine, Child health, Infant nutrition (including breastfeeding), Diabetes, Metabolic disorders Short research reports Source Type: research

Pages: 1  2