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Maternal allopurinol administration during suspected fetal hypoxia: a novel neuroprotective intervention? A multicentre randomised placebo controlled trial
Conclusions Maternal treatment with allopurinol during fetal hypoxia did not significantly lower neuronal damage markers in cord blood. Post hoc analysis revealed a potential beneficial treatment effect in girls. Trial registration number NCT00189007, Dutch Trial Register NTR1383.
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - April 17, 2015 Category: Perinatology & Neonatology Authors: Kaandorp, J. J., Benders, M. J. N. L., Schuit, E., Rademaker, C. M. A., Oudijk, M. A., Porath, M. M., Oetomo, S. B., Wouters, M. G. A. J., van Elburg, R. M., Franssen, M. T. M., Bos, A. F., de Haan, T. R., Boon, J., de Boer, I. P., Rijnders, R. J. P., Jac Tags: Clinical trials (epidemiology), Stroke Original articles Source Type: research

Rapid target allopurinol concentrations in the hypoxic fetus after maternal administration during labour
Conclusions A dose of 500 mg intravenous allopurinol rapidly crosses the placenta and provides target concentrations in 95% of the fetuses at the moment of delivery, which makes it potentially useful as a neuroprotective agent in perinatology with very little side effects. Trial registration The study is registered in the Dutch Trial Register (NTR1383) and the Clinical Trials protocol registration system (NCT00189007).
Source: Archives of Disease in Childhood - Fetal and Neonatal Edition - February 13, 2014 Category: Perinatology & Neonatology Authors: Kaandorp, J. J., van den Broek, M. P. H., Benders, M. J. N. L., Oudijk, M. A., Porath, M. M., Bambang Oetomo, S., Wouters, M. G. A. J., van Elburg, R., Franssen, M. T. M., Bos, A. F., Mol, B. W. J., Visser, G. H. A., van Bel, F., Rademaker, C. M. A., Derk Tags: Stroke, Medicines regulation Original articles Source Type: research