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Synthesis and biological evaluation of resveratrol amide derivatives as selective COX-2 inhibitors
Chem Biol Interact. 2023 May 11:110522. doi: 10.1016/j.cbi.2023.110522. Online ahead of print.ABSTRACTSelective COX-2 inhibitors have been considered to be reliable alternatives to tNSAIDs, but most of them were withdrawn from the market due to their risk of heart attack and stroke. Therefore, it is urgent to develop a new type of selective COX-2 inhibitor with high efficiency and low toxicity. Inspired by the cardiovascular protection, and anti-inflammatory activity of resveratrol, we synthesized 38 resveratrol amide derivatives and evaluated their COX-1/COX-2 inhibitory activities. Compounds 8a, 6a, 8c and 13c showed imp...
Source: Chemico-Biological Interactions - May 13, 2023 Category: Molecular Biology Authors: Min Xin Haoyu Wu Yuan Du Sheng Liu Feng Zhao Xiaofeng Mou Source Type: research