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Source: Free Radical Biology and Medicine
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Total 77 results found since Jan 2013.
Hyperglycemia exacerbates ischemic stroke not through increased generation of hydrogen peroxide
Free Radic Biol Med. 2023 Aug 3:S0891-5849(23)00576-2. doi: 10.1016/j.freeradbiomed.2023.08.004. Online ahead of print.ABSTRACTDiabetes is one of the significant risk factors for ischemic stroke. Hyperglycemia exacerbates the pathogenesis of stroke, leading to more extensive cerebral damage and, as a result, to more severe consequences. However, the mechanism whereby the hyperglycemic status in diabetes affects biochemical processes during the development of ischemic injury is still not fully understood. In the present work, we record for the first time the real-time dynamics of H2O2 in the matrix of neuronal mitochondria ...
Source: Free Radical Biology and Medicine - August 5, 2023 Category: Biology Authors: Daria A Kotova Alexandra D Ivanova Matvei S Pochechuev Ilya V Kelmanson Yulia V Khramova Alisa Tiaglik Mark A Sudoplatov Arina P Trifonova Anna Fedotova Kseniia Morozova Veronika A Katrukha Anastasia D Sergeeva Roman I Raevskii Mariia P Pestriakova Maxim Source Type: research
Lithium Co-administration with rutin improves post-stroke neurological outcomes via suppressing Gsk-3 β activity in a rat model
Free Radic Biol Med. 2023 Jul 4:S0891-5849(23)00522-1. doi: 10.1016/j.freeradbiomed.2023.07.004. Online ahead of print.ABSTRACTCerebral ischemic stroke is one of the leading causes of adult disability worldwide. Reperfusion is the only therapeutic option with a lot of side effects. In the current study, we investigated the efficacy of rutin and lithium co-treatment in improving post-stroke neurological outcomes in a transient global cerebral ischemia-reperfusion injury rat model. Middle-aged male rats were subjected to transient global cerebral ischemia-reperfusion. NORT and Y-maze were used to assess the cognitive process...
Source: Free Radical Biology and Medicine - July 6, 2023 Category: Biology Authors: Anil Kumar Rana Rajneesh Kumar Durgesh Nandan Shukla Damanpreet Singh Source Type: research
Altered trafficking of miRNAs at mitochondria modulates mitochondrial functions and cell death in brain ischemia
Free Radic Biol Med. 2023 Feb 11:S0891-5849(23)00053-9. doi: 10.1016/j.freeradbiomed.2023.02.004. Online ahead of print.ABSTRACTStroke is one of the major causes of death and disabilities worldwide. The rapid induction of cell death by necrosis and apoptosis is observed at the ischemic core, while long lasting apoptosis and brain inflammation continue in the penumbra. The emerging evidence suggests a critical role of mitochondria in acute and chronic inflammation and cell death. Mitochondrial dysfunction may result in the release of mitokines and/or mitochondrial DNA into the cytoplasm and activate multiple cytosolic pathw...
Source: Free Radical Biology and Medicine - February 13, 2023 Category: Biology Authors: Dhruv Gohel Shatakshi Shukla Wenson David Rajan Bartosz Wojtas Bozena Kaminska Rajesh Singh Source Type: research
Elabela-APJ axis attenuates cerebral ischemia/reperfusion injury by inhibiting neuronal ferroptosis
Free Radic Biol Med. 2023 Jan 18:S0891-5849(23)00009-6. doi: 10.1016/j.freeradbiomed.2023.01.008. Online ahead of print.ABSTRACTFerroptosis is a form of non-apoptotic cell death caused by iron-dependent peroxidation of lipids. It contributes to ischemic stroke-induced neuronal damage. Elabela (ELA), a novel endogenous ligand for Apelin receptor (APJ), regulates oxidative stress and exerts a protective role in cardiovascular disease. However, the effect of ELA-APJ axis on cellular ferroptosis in cerebral ischemia/reperfusion (I/R) remains elusive. The present study showed that ELA and APJ were expressed on neurons and incre...
Source: Free Radical Biology and Medicine - January 21, 2023 Category: Biology Authors: Pengfei Xu Lingqi Kong Chunrong Tao Yuyou Zhu Juan Cheng Wenyu Li Nan Shen Rui Li Chao Zhang Li Wang Yan Zhang Guoping Wang Xinfeng Liu Wen Sun Wei Hu Source Type: research
Taurine attenuates neuronal ferroptosis by regulating GABA < sub > B < /sub > /AKT/GSK3 β/β-catenin pathway after subarachnoid hemorrhage
Free Radic Biol Med. 2022 Nov 16:S0891-5849(22)00965-0. doi: 10.1016/j.freeradbiomed.2022.11.003. Online ahead of print.ABSTRACTFerroptosis, characterized by lipid peroxidation and intracellular iron accumulation, has been reported to be involving in the pathophysiological of early brain injury (EBI) after subarachnoid hemorrhage (SAH). Although taurine reportedly yields neuroprotective effects in multiple central neurological diseases and can attenuated neuron damage after stroke, its role in EBI after SAH remains unclear. The present study indicated that taurine levels in cerebrospinal fluid were significantly reduced in...
Source: Free Radical Biology and Medicine - November 19, 2022 Category: Biology Authors: Chengli Liu Peibang He Yujia Guo Qi Tian Jianfeng Wang Guijun Wang Zhan Zhang Mingchang Li Source Type: research
Age- and sex-dependent effects of DNA glycosylase Neil3 on amyloid pathology, adult neurogenesis, and memory in a mouse model of Alzheimer's disease
Free Radic Biol Med. 2022 Nov 14:S0891-5849(22)00983-2. doi: 10.1016/j.freeradbiomed.2022.11.020. Online ahead of print.ABSTRACTOxidative stress generating DNA damage has been shown to be a key characteristic in Alzheimer's disease (AD). However, how it affects the pathogenesis of AD is not yet fully understood. Neil3 is a DNA glycosylase initiating repair of oxidative DNA base lesions and with a distinct expression pattern in proliferating cells. In brain, its function has been linked to hippocampal-dependent memory and to induction of neurogenesis after stroke and in prion disease. Here, we generated a novel AD mouse mod...
Source: Free Radical Biology and Medicine - November 17, 2022 Category: Biology Authors: Milena A Egiazarian Silje Str ømstad Teri Sakshaug Ana B Nunez-Nescolarde Nicole Bethge Magnar Bj ørås Katja Scheffler Source Type: research
