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Associations of estradiol levels and genetic polymorphisms of inflammatory genes with the risk of ischemic stroke
In this study, we analyzed the effect of a polygenic risk score (PRS) constructed using inflammatory genes...
Source: Journal of Biomedical Science - March 28, 2017 Category: Biomedical Science Authors: Yi-Chen Hsieh, Fang-I Hsieh, Yih-Ru Chen, Chaur-Jong Hu, Jiann-Shing Jeng, Sung-Chun Tang, Nai-Fang Chi, Huey-Juan Lin, Li-Ming Lien, Giia-Sheun Peng and Hung-Yi Chiou Source Type: research

Research Articles The prodrug DHED selectively delivers 17{beta}-estradiol to the brain for treating estrogen-responsive disorders
Many neurological and psychiatric maladies originate from the deprivation of the human brain from estrogens. However, current hormone therapies cannot be used safely to treat these conditions commonly associated with menopause because of detrimental side effects in the periphery. The latter also prevents the use of the hormone for neuroprotection. We show that a small-molecule bioprecursor prodrug, 10β,17β-dihydroxyestra-1,4-dien-3-one (DHED), converts to 17β-estradiol in the brain after systemic administration but remains inert in the rest of the body. The localized and rapid formation of estrogen from the ...
Source: Science Translational Medicine - July 22, 2015 Category: Biomedical Science Authors: Prokai, L., Nguyen, V., Szarka, S., Garg, P., Sabnis, G., Bimonte-Nelson, H. A., McLaughlin, K. J., Talboom, J. S., Conrad, C. D., Shughrue, P. J., Gould, T. D., Brodie, A., Merchenthaler, I., Koulen, P., Prokai-Tatrai, K. Tags: Research Articles Source Type: research