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Specialty: Biochemistry
Source: Molecular and Cellular Biochemistry

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Total 26 results found since Jan 2013.

Exosomes from circRNA-Ptpn4 can modify ADSC treatment and repair nerve damage caused by cerebral infarction by shifting microglial M1/M2 polarization
This study showed that exosomes from hypoxia pretreatment of ADSCs had significant effects in promoting functional recovery following in vivo MCAO, through suppressed inflammatory factor expression, and shifting the microglial from M1 to M2 polarization activation. The results showed that circRNA-Ptpn4 was highly expressed during hypoxia pretreatment of ADSCs exosomes. Exosomes from circ-Ptpn4-modified ADSCs had a greater ability to promote functional recovery. The circ-Ptpn4 delivered from ADSC exosomes induced microglia/macrophage polarization from M1 to M2 by suppressing miR-153-3p and enhancing Nrf2 expressions. Taken ...
Source: Molecular and Cellular Biochemistry - August 26, 2023 Category: Biochemistry Authors: Fei Wang Mei Jiang Yongbin Chi Gang Huang Mingming Jin Source Type: research

The potential therapeutic effect of phosphodiesterase 5 inhibitors in the acute ischemic stroke (AIS)
In conclusion, PDE5 inhibitors may have potential roles in the management of AIS through modulation of CBF, cAMP/cGMP/NO pathway, neuroinflammation, and inflammatory signaling pathways. Preclinical and clinical studies are recommended in this regard.PMID:37395897 | DOI:10.1007/s11010-023-04793-1
Source: Molecular and Cellular Biochemistry - July 3, 2023 Category: Biochemistry Authors: Raed AlRuwaili Hayder M Al-Kuraishy Mubarak Alruwaili Amira Karam Khalifa Athanasios Alexiou Marios Papadakis Hebatallah M Saad Gaber El-Saber Batiha Source Type: research

Role of sirtuins in attenuating plaque vulnerability in atherosclerosis
Mol Cell Biochem. 2023 Mar 23:1-12. doi: 10.1007/s11010-023-04714-2. Online ahead of print.ABSTRACTAtherosclerosis is characterized by the development of intimal plaque, thrombosis, and stenosis of the vessel lumen causing decreased blood flow and hypoxia precipitating angina. Chronic inflammation in the stable plaque renders it unstable and rupture of unstable plaques results in the formation of emboli leading to hypoxia/ischemia to the organs by occluding the terminal branches and precipitate myocardial infarction and stroke. Such delibitating events could be controlled by the strategies that prevent plaque development o...
Source: Molecular and Cellular Biochemistry - March 23, 2023 Category: Biochemistry Authors: Prathosh Velpuri Vikrant Rai Devendra K Agrawal Source Type: research

Role of oncostatin-M in ECM remodeling and plaque vulnerability
Mol Cell Biochem. 2023 Mar 1. doi: 10.1007/s11010-023-04673-8. Online ahead of print.ABSTRACTAtherosclerosis is a multifactorial inflammatory disease characterized by the development of plaque formation leading to occlusion of the vessel and hypoxia of the tissue supplied by the vessel. Chronic inflammation and altered collagen expression render stable plaque to unstable and increase plaque vulnerability. Thinned and weakened fibrous cap results in plaque rupture and formation of thrombosis and emboli formation leading to acute ischemic events such as stroke and myocardial infarction. Inflammatory mediators including TREM-...
Source: Molecular and Cellular Biochemistry - March 1, 2023 Category: Biochemistry Authors: Parth Patel Vikrant Rai Devendra K Agrawal Source Type: research

Beneficial effects of buspirone in endothelin-1 induced stroke cachexia in rats
Mol Cell Biochem. 2023 Jan 7. doi: 10.1007/s11010-022-04653-4. Online ahead of print.ABSTRACTStroke cachexia is associated with prolonged inflammation, muscle loss, poor prognosis, and early death of stroke patients. No particular treatment is available to cure the symptoms or disease. The present study aimed to evaluate the effect of a 5-HT1a agonist, buspirone on stroke cachexia. Wistar rats were injected with endothelin-1 to the bregma region of the brain to induce ischemic stroke followed by induction of cachexia after 4 days. Treatment with buspirone (3 mg/kg p.o) was given for 4 weeks after confirmation of cachexia i...
Source: Molecular and Cellular Biochemistry - January 7, 2023 Category: Biochemistry Authors: Darshak Shah Mit Joshi Jigna Shah Bhoomika M Patel Source Type: research

EndMT-derived mesenchymal stem cells: a new therapeutic target to atherosclerosis treatment
Mol Cell Biochem. 2022 Sep 9. doi: 10.1007/s11010-022-04544-8. Online ahead of print.ABSTRACTCardiovascular diseases, such as coronary artery disease and stroke, are the main threats to human health worldwide. Atherosclerosis, a chronic inflammatory disorder, plays a role as an initiator of all of the above-mentioned diseases. Cell therapy for diseases has attracted widespread attention. Mesenchymal stem cells (MSCs) are a type of stem cell that still exist in adults and have the characteristics of self-renewal ability, pluripotent differentiation potential, immunomodulation, tissue regeneration, anti-inflammation and low ...
Source: Molecular and Cellular Biochemistry - September 9, 2022 Category: Biochemistry Authors: Xiaofan Zhang Zhong Ren Zhisheng Jiang Source Type: research

Microrheological disorders in patients with polycythemia vera suffered acute ischemic stroke
Mol Cell Biochem. 2022 Jan 4. doi: 10.1007/s11010-021-04352-6. Online ahead of print.ABSTRACTThe relevance of the study is determined by the fact that the combination of cerebrovascular disorders and myeloproliferative diseases requires the search for a predictive biomarker to improve outcomes. The aim of this article was to explore the meanings of microrheological disorders in patients with polycythemia vera (PV) who suffered an acute ischemic stroke (AIS). The study was carried out at the Research center of Neurology. We studied microrheological properties in 181 patients (aged 42-75 years). From the AIS developed in 68 ...
Source: Molecular and Cellular Biochemistry - January 5, 2022 Category: Biochemistry Authors: Marine Tanashyan Alla Shabalina Eugene Roitman Source Type: research

Mitochondrial DAMPs and altered mitochondrial dynamics in OxLDL burden in atherosclerosis.
Abstract Atherosclerosis results in life-threatening cardiovascular pathologies, including ischemic heart disease, stroke, myocardial infarction, and peripheral arterial disease. The role of increased serum low-density lipoprotein (LDL) and resultant accumulation of oxidized-LDL (oxLDL) in atheroma formation is well established. Recent findings elucidate the significance of mitochondrial damage-associated molecular patterns (mtDAMPs) in triggering sterile inflammation in concert with oxLDL. The mtDAMPs including mitochondrial DNA (mtDNA), cytochrome C, cardiolipin, heat shock protein 60 (HSP60), mitochondrial tran...
Source: Molecular and Cellular Biochemistry - January 25, 2021 Category: Biochemistry Authors: Khwaja B, Thankam FG, Agrawal DK Tags: Mol Cell Biochem Source Type: research

Myricitrin  ameliorates cognitive deficits in MCAO cerebral stroke rats via histone acetylation-induced alterations of brain-derived neurotrophic factor.
Myricitrin ameliorates cognitive deficits in MCAO cerebral stroke rats via histone acetylation-induced alterations of brain-derived neurotrophic factor. Mol Cell Biochem. 2020 Oct 19;: Authors: Gao Y, Ya B, Li X, Guo Y, Yin H Abstract The present study screened the effect of Myricitrin on cognitive deficits post-cerebral ischemic stroke and the involved mechanism. The rats were submitted to middle cerebral artery occlusion (MCAO) and were treated with sodium butyrate or Myricitrin (15 and 30 mg/kg) for 28 days. The spatial memory was studied by Morris water maze (MWM). After 4 weeks, the rats w...
Source: Molecular and Cellular Biochemistry - October 19, 2020 Category: Biochemistry Authors: Gao Y, Ya B, Li X, Guo Y, Yin H Tags: Mol Cell Biochem Source Type: research

Dexmedetomidine had neuroprotective effects on hippocampal neuronal cells via targeting lncRNA SHNG16 mediated microRNA-10b-5p/BDNF axis.
In conclusion, DEX exerts neuroprotective in ischemic stroke via improving neuron damage, the underlying mechanism may be upregulating SHNG16 and BDNF via sponging miR-10b-5p. PMID: 32323054 [PubMed - as supplied by publisher]
Source: Molecular and Cellular Biochemistry - April 21, 2020 Category: Biochemistry Authors: Wang L, Liu W, Zhang Y, Hu Z, Guo H, Lv J, Du H Tags: Mol Cell Biochem Source Type: research

MALAT1 affects hypoxia-induced vascular endothelial cell injury and autophagy by regulating miR-19b-3p/HIF-1 α axis.
MALAT1 affects hypoxia-induced vascular endothelial cell injury and autophagy by regulating miR-19b-3p/HIF-1α axis. Mol Cell Biochem. 2020 Jan 13;: Authors: Liu H, Shi C, Deng Y Abstract Cardiovascular disease has become the leading cause of death in the world. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) plays an important role in cardiovascular disease, such as stroke. However, the role of MALAT1 in hypoxia (HYP)-induced vascular endothelial cells (VECs) remains unclear. In the present study, HYP-treated human umbilical vein endothelial cells (HUVECs) were utilized to simulate HY...
Source: Molecular and Cellular Biochemistry - January 12, 2020 Category: Biochemistry Authors: Liu H, Shi C, Deng Y Tags: Mol Cell Biochem Source Type: research

Curcumin amends Ca2+ dysregulation in microglia by suppressing the activation of P2X7 receptor.
Abstract Curcumin (Cur) is widely used as an anti-inflammation agent and has anti-depression potential. Neuroinflammation mediated by Ca2+ channel activation is closely associated with the progression of post-stroke depression (PSD). In the current study, the role of P2X7 receptor (P2X7R) in the anti-PSD function of Cur was explored. Rats were subjected to middle cerebral artery occlusion (MCAO) surgery and chronic mild stress administration to induce PSD symptoms and then treated with Cur. The behaviors of rats were assessed with sucrose preference and forced swim tests. The accumulation of Ca2+ and the systemic ...
Source: Molecular and Cellular Biochemistry - December 31, 2019 Category: Biochemistry Authors: Wang Z, Ren W, Zhao F, Han Y, Liu C, Jia K Tags: Mol Cell Biochem Source Type: research

Distinct proteomic profiles in monozygotic twins discordant for ischaemic stroke.
Abstract Stroke is a common disorder with significant morbidity and mortality, and complex aetiology involving both environmental and genetic risk factors. Although some of the major risk factors for stoke, such as smoking and hypertension, are well-documented, the underlying genetic and detailed molecular mechanisms remain elusive. Exploring the relevant biochemical pathways may contribute to the clinical diagnosis of stroke and shed light on its aetiology. A comparative proteomic analysis of blood serum of a pair of monozygotic (MZ) twins discordant for ischaemic stroke (IS) was performed using a label-free quan...
Source: Molecular and Cellular Biochemistry - January 29, 2019 Category: Biochemistry Authors: Vadgama N, Lamont D, Hardy J, Nasir J, Lovering RC Tags: Mol Cell Biochem Source Type: research